摘要
目的研究肝肠钙粘连蛋白在不同分化程度的直肠癌组织中的表达及其与直肠癌生物学行为之间的关系,探讨肝肠钙粘连蛋白表达与直肠癌发生及发展之间的相关性。方法采用免疫组化S-P法,检测肝肠钙粘连蛋白在70例不同分化程度的直肠癌组织以及5例正常及炎症直肠组织中的表达,并结合临床病理参数进行相关分析。结果 70例不同分化程度的直肠癌组织中,肝肠钙粘连蛋白表达下调29例,表达下调率41.43%。5例正常或炎症组织中肝肠钙粘连蛋白表达下调0例,两者比较,差异无统计学意义(P>0.05)。直肠组织中肝肠钙粘连蛋白的表达下调与肿瘤的分化程度、有无淋巴结转移、pTNM分期有关(P<0.05);而与年龄、性别、肿瘤的病理类型以及是否有远处转移无关(P>0.05)。结论直肠癌组织中肝肠钙粘连蛋白表达下调与直肠癌的发展过程密切相关,它可作为反映直肠癌恶性生物学行为的一个可靠指标。
Objective To investigate the expression of liver-intestine（LI） cadherin in rectal carcinoma and the rela- tionship between expression of LI-cadherin and biological behavior and the correlation of it and the development of rectal carcinoma. Methods The expression of LI-cadherin in 70 rectal carcinoma and 5 normal rectal tissue was examined by S-P immunohistochemistrical staining, and the correlation of LI-cadherin expression and clinical parameters was ana- lyzed. Results The expression of LI-cadherin in rectal carcinoma was not obviously lower than that in normal colon tis- sue. 29 of 70 cases（41.43% ） were reduced expression of LI-cadherin. Reduced LI-cadherin expression was signifi cantly associated with high tumor grade, lymph node metastasis, advanced pTNM stage and depth of invasion; while it was not associated with age, gender, pathological category and distance metastasis. Conclusion Reduced expression of LI-cadherin may contribute to the development of rectal carcinoma, and might be a reliable indicator to reflect the bio- logical behavior of rectal carcinoma.
出处
《胃肠病学和肝病学杂志》
CAS
2012年第6期515-517,共3页
Chinese Journal of Gastroenterology and Hepatology
