摘要
用Beagle犬急性心肌梗塞后室性心律失常模型研究了SIPI-644对心梗后24和48h室性心律失常的治疗作用。SIPI-644iv7.3～29.2mg/kg, 能非常显著地提高窦性心率占总心率的百分率(SR％),窦性节律明显增加,室性节律明显减少或完全消失,作用持续达1h,且作用和剂量相关。抗心律失常作用比利多卡因和奎尼丁强。
Two-stage LAD ligation was performed according to Harris inbeagle dogs. SIPI-644 at the doses of 7.3～29.2 mg/kg iv increased significantlythe percentage of normal sinus beats and decreased total HR. The antiarrhythmiceffect of SIPI-644 lasted 0.5 to 1 h. The result indicated that SIPI-644 possessedstronger therapeutic effect than lidocaine or quinidine on post-infarction ventriculararrhythmia in beagle dogs.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1990年第12期548-549,共2页
Chinese Journal of Pharmaceuticals
关键词
SIPI-644
心律失常
心肌梗塞
药理
methylflavonolamide hydrochloride (SIPI-644), antiarrhythmic effect
infarction
ventricular arrhythmia
