摘要
用乌头碱诱发的大鼠室性心律失常模型观察了SIPI-644十二指肠给药(id)的抗心律失常作用。本品id 50,100和200 mg/kg,均能显著对抗乌头碱诱发的各种室性心律失常,但三个剂量组之间没有明显差异p>0.05),抗心律失常作用的强度和剂量没有明显相关性。其id的药效比iv的药效弱,它和胺碘酮、静注的ED_(50)分别为12.3和27.8mg/kg,它们约TI分别为11.7和5.3。
Intraduodenal administration of SIPI-644 at doses of 50, 100 and200 mg/kg significantly increased the threshold doses of aconitine to induce ven-tricular premature beats (VPB), short ventricular tachycardia (SVT), ventriculartachycardia (VT) and ventricular fibrillation (VF) in rats. However, its antiar-rhythmic effect did not parallel to the id dose of SIPI-644. The iv ED_(50) of SIPI-644 and amiodarone determined on aconitine-induced arrhythmia in rats were12.3 and 27.8 mg/kg, respectively. The iv therapeutic index(TI) of SIPI-644and amiodarone were 11.7 and 5.3.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1989年第10期452-454,共3页
Chinese Journal of Pharmaceuticals
关键词
SIPI-644
心律失常
乌头碱
鼠
4'-methyl-7-[2-hydroxy-3-[β-(propionamido)ethyl amino] propoxy]flavone hydrochloride (SIPI-644), anti-arrhythmia, intraduodenal administration,aconitine
