摘要
目的：通过动物实验，采用不同给药途径研究比较罂粟碱、尼莫同对脑血管痉挛(Cerebral Vasospasm, CVS)的治疗效果方法：采用枕大池注入自体动脉血建立兔CVS动物模型，然后分成4组，分别采用经颈内动脉、周围动脉和静脉给予不同的药物，在SAH形成前、形成后3 d及第14 d 分别测量颈内动脉颅内段血流速度(Blood Flow Velociy, BFV)、颈内动脉颅内段管径，并在光镜下观察颈内动脉颅内段及大脑组织病理变化结果：罂粟碱颈动脉内注射组的BFV较罂粟碱静脉内、尼莫同动脉或静脉注射组的BFV明显降低；管径增加；病理变化最轻结论：罂粟碱经颈内动脉注射在晚期的解痉效果优于罂粟碱静脉注射。
Aim: To Study the curative effects of papaverine and nimodipine on cerebral vasospasm. Methods: The SAH models of rabbits were produced by injection of fresh autologous nonheparinized arterial blood into magna cisterna, then were divided into four groups, treated by different drugs and injection methods. after 14 days, their blood flow velocities, diameters: tissues of the intracranial sections of ICAS were examined respectively. Results: The BFV of papaverine (IA) signifficantly decreased compared to that of papaverine(IV), nimodipine (IV) and nimodipine (IA); The diameters were increased and the pathology changes were the most smallest. Conclusion： The curative effects of papaverine injected into ICA is the most effectivest in late time.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
2000年第1期105-108,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
