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神经介入术中脑血管痉挛的预防与处理 被引量:10

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摘要 目的探讨神经介入术中脑血管痉挛(CVS)的发生机制与处理方法。方法总结神经介入手术过程出现和/或血管痉挛加剧,造成血管闭塞的6例患者,术中采用动脉灌注罂粟碱、法舒地尔抗血管痉挛药物,解除血管痉挛。结果3例因操作器械刺激诱发血管痉挛导致血管闭塞,术中经动脉内灌注解痉药物,10~15min痉挛接触,血管再通,血流恢复。3例DSA全脑血管造影时已显示血管痉挛征象,手术过程中痉挛加重导致血管闭塞,动脉内灌注药物后痉挛解除。结论术前2h开始静滴尼莫地平维持治疗,有利于降低CVS发生的几率,是预防严重CVS的措施之一。对于术中发生的严重CVS,动脉内灌注罂粟碱、法舒地尔是解除痉挛的有效方法。
出处 《中国现代医生》 2008年第24期76-76,78,共2页 China Modern Doctor
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  • 1Nakamura K,Nishimura J,Hirano K,et al.Hydroxyfasudil,an active metabolice of fasudil hydrochloride,relaxes the rabbit basilar artery by disinibition of myosin light chain phosphatase.J Cereb Blood Flow Metab,2001,21:876-885.
  • 2Masumoto N,Tanabe Y,Saito M,et al.Attenuation of pressure-induced myogenic contraction and tyrosine phosphorylation by fasudil,a cerebral vasodilator,in rat cerebral artery.British journal of pharmacology,2000,130:219-230.
  • 3Takanashi Y,Ishida T,Meguro T,et al.A novel drug delivery system as prophylaxis for cerebral vasospasm.Acta Neurochir,2001,(Suppl) 77:213-215.
  • 4Masaoka H,Takasato Y,Nojiri T,et al.Clinic effect of fasudil hydrochloride for cerebral vasospasm following subarachnoid hemorrhage.Acta Neurochir,2001,(Suppl) 77:209-221.
  • 5Miriam M T,Bernhard W,Peter M S,et al.Systematic review of the prevention of delayed ischemic neurological deficits with hypertension,hypervolemia,and hemodilution therapy following subarachnoid hemorrhage.J Neurosurg,2003,98:978-984.
  • 6Nagumo H,Sasaki Y,Ono Y,et al.Rho-kinase inhibitor HA-1077 prevents rho-mediated myosin phosphatase inhibition in smooth muscle cells.Am J Physiol,2000.278:C57-C65.
  • 7Sasaki Y,Suzuki M,Hidaka H.The noval and specific rhokinase inhibitor (s)-(+) -2-Methyl-1-[(4-methyl-5 -isoquinoline) sulfony] -Homopiperazine as a probing molecule for rho-kinase-invlved pathway.Phrmacology & Therapeutics,2002,93:225-232.
  • 8Satoh Sh,Suzuki I,Ikegaki I,et al.The effects of HA 1077on the cerebral circulation after subarachnoid haemorrhage in dogs.Acta Neurochir (Wien),1991,110:185-188.
  • 9Shibuya M,Suzuki Y,Sugita K,et al.Effect of AT877 on cerebral vasospasm after aneurysmal subaracnoid hemorrhage.J Neurosurg,1992,76:571-577.
  • 10Shibuya M,Asano T,Sasaki Y.Effect of fasudil HCl,a protein kinase inhibitor,on cerebral vasospasm.Acta Neurochir,2000,(Suppl) 77:201-204.

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