摘要
目的研究鞘内注射罂粟碱对实验性脑血管痉挛的治疗作用。方法采用免自体动脉血枕大池注射模型,经鞘内给罂粟碱,用经颅多谱勒检测基底动脉血流速度(BFV),以BFV超过术前10 cm／s为脑血管痉挛复制成功的标志,并以此判断脑血管痉挛的变化。结果鞘内注射罂粟碱可以缓解实验性脑血管痉挛,BFV由(23．20±4．05)cm／s降至(11．52±5．12)cm／s。在对照组基底动脉也有脑血管的扩张,在蛛网膜下腔出血(SAH)14 d后脑血管壁出现多种病理改变,平滑肌细胞出现空泡变性,罂粟碱不再发挥作用。结论在SAH后早期鞘内使用罂粟碱对实验性脑血管痉挛有治疗作用。
Objective To evaluate the effect of intrathecal infusion of papaverine for the prevention of vasospasm following subarachnoid hemorrhage （SAH）. Methods A cerebral vasospasm model was established in rabbits by injecting self artery blood into cistern, Vasospasm was diagnosed by Doppler identifying blood flow velocity （BFV） being increased more than 10 cm/s. Results After intrathecal infusion of papaverine, BFV was decreased from （23,20 ± 4.05 ） cm/s to （ 11.52 ± 5.12） cm/s. Papaverine could release normal cerebral arteries, too. But papaverine could not affect cerebral artery 14 days following SAH, because other pathological changes occurred in the vessels. Conclusion In the early stage after SAH, intrathecal infusion of papaverine is helpful for the prevention of vasospasm following SAH.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2005年第12期1528-1529,共2页
Chinese Journal of Experimental Surgery
