摘要
目的 探讨表皮生长因子（ＥＧＦ）和表皮生长因子受体（ＥＧＦＲ）在胃癌的表达及与胃癌发生发展的关系。方法 采用免疫组化Ｓ—Ｐ法对正常胃粘膜（ｎ＝５），各级胃粘膜异型增生（轻度ｎ＝９，中度ｎ＝６，重度ｎ＝５），早期胃癌（ｎ＝１０），进展期胃癌（ｎ＝４０），癌旁组织（ｎ＝２７）进行研究。结果 ＥＧＦ及ＥＧＦＲ在正常胃粘膜中均为阴性，在异型增生病变中随异型增生程度的增加，阳性率逐渐升高。ＥＧＦ在轻、中、重度异型增生中的阳性率分别为２２．２％（２／９）、５０％（３／６）和８０ ％（４／５）；ＥＧＦＲ在轻、中、重度异型增生中的阳性率分别为３３．３％（３／９）、６６．７％（４／６）、６０％（３／５）。ＥＧＦ和ＥＧＦＲ在早期胃癌中的阳性率均为２０％（２／１０）；在进展期胃癌的阳性率分别为６２．５％（２５／４０）和６０％（２４／４０）。进展期胃癌ＥＧＦ和ＥＧＦＲ的阳性率显著高于早期胃癌（Ｐ＜０．０５），癌旁异常组织组的ＥＧＦ和ＥＧＥＲ阳性率均高于癌旁正常组织组（７７．８％ｖｓ２２．２％，Ｐ＜０．０５。８３．３％ｖｓ４４．４％，Ｐ＜０．０５）。结论 ＥＧＦ及ＥＧＦＲ参与了胃癌的发生、发展，是胃癌前病变的一项有意义的标志物。
Objectire To study the expression and significance of EGF and EGFR in the Process of gastric carcinogenisis. Methods: S- P im- munohistochemical method was used to examine the expression of EGF and EGFR in 75cases (5 normal gastric mucosas, 20 gastric mucosas, 50 gastric carcinomas and 27 paracarcinomas tissues). Results:Normal gastric mucosa was negative for EGF and EGFR. Increased expression of EGF and EGFR was found in slight,moderate and severe dysplasia. EGF expreession was 22.2%,50% and 80%, EGFR expression was 33.3%, 66. 7% and 60%. The positive rates of EGF and EGFR in early gastric carcinomas were both 20%. The positive rates of EGF and EGFR in advanced gastric carcinomas were 62. 5% and 60% respectivly. The positive rates of EGF and EGFR in advanced gastric carcinomas were significantly high- er than those in early gastric carcinomas (P < 0. 05). The positive rates of EGF and EGFR in paracarcinomas abnomal tissues were significantly higher than those in paracarcinomas nomal tissues (77. 8% vs 22.2%, P <0.05. 83.3% vs 44.4%, P <0.05). Conclusion:EGF and EGFR positive expression might play an important role in the process of carcinogenesis of gastric mucosa and might serve as an important molecular marker of gastric premalignant lesions.
出处
《重庆医学》
CAS
CSCD
2000年第3期196-197,共2页
Chongqing medicine
关键词
表皮生长因子
胃肿瘤
癌前病变
EGTR
免疫组化
epidermal growth factor
epidermal growth factor
epidermal growth factor receptor
stomach neoplams
precancerous lesions
immmunohistochemistry
