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表皮生长因子受体在皮肤良恶性肿瘤中的表达 被引量:3

Epidermal growth factor receptor in the benign and malignant skin tumors
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摘要 为探讨表皮生长因子受体(EGFR)与皮肤肿瘤的关系,作者用流式细胞免疫荧光技术,检测了33例皮肤良恶性变。结果显示:EGFR的相对含量荧光指数(FI)在恶性肿瘤中的表达明显高于良性肿瘤(P<0.001)。提示EGFR在肿瘤的生、发展中也起着重要的作用。 In order to explore the relation betw een epidermal growth factor recepto r(EGFR)and the skin tumors,33cases of vario us skin tumors were analysed with immunofluorescence staining technique a nd flow cytometry.The results showe d that the fluores-cence index(FI )representing the relative content o f EGFR in malignant skin tumors was all higher than that in benign ones(P<0.001).This suggested that the EGFR was very likely to play an important role in t he development and progress of the sk in ma-lignant tumors.
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2002年第2期81-82,共2页 Journal of Clinical Dermatology
关键词 皮肤肿瘤 表皮生长因子受体 良恶性肿瘤 EGFR 脂溢性角化病 角化棘皮瘤 鳞状细胞癌 Tumors,skin Receptor,epidermal g rowth factor Seborrheic keratosis Keratoacanthoma Squamous-cell c arcinoma
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参考文献10

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二级参考文献2

  • 1Paul W. Brandt-Kauf,Regina Monaco,Matthew R. Pincus. Conformation of the transmembrane domain of the epidermal growth factor receptor[J] 1994,Journal of Protein Chemistry(2):227~231
  • 2Mayumi Naramura,Stephen D. Gillies,John Mendelsohn,Ralph A. Reisfeld,Barbara M. Mueller. Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma[J] 1993,Cancer Immunology Immunotherapy(5):343~349

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