摘要
采用直接磺化法合成了 3种不同取代度的磺化β-环糊精 ,并对合成产物进行了表征。将这 3种负电性的β-环糊精衍生物应用于毛细管电泳手性化合物的拆分研究中 ,考察了不同 p H值和不同电极性条件下负电性磺化β-环糊精对手性化合物的立体选择作用。
Three new kinds of the sodium salt of sulfonated β-cyclodextrins with different degrees of substitution were synthesized and characterized. A simple synthesis method was employed by direct sulfonating reaction with concentrated sulfuric acid. Sulfonated β-cyclodextrins were used as chiral resolving agents for the capillary electrophoretic separation of enantiomers in high pH and low pH background electrolytes. In different electrophoretic polarity mode, the effects of the type and concentration of sulfonated β-cyclodextrin were investigated. Sulfonated β-cyclodextrins were proved to be strong complexing agents for basic and neutral analytes.
出处
《色谱》
CAS
CSCD
北大核心
2000年第2期183-186,共4页
Chinese Journal of Chromatography
基金
国家自然科学基金! (2 9475 2 1 7)
兰州化学物理研究所所长基金
关键词
毛细管电泳
磺化β-环糊精
合成
手性拆分
capillary electrophoresis
sulfonated β-cyclodextrin
chiral additive
enantiomeric separation
