摘要
对 7 乙基 1 0 羟基喜树碱的制备进行了研究 ,优化了合成工艺 ,使总收率由 1 9.7%提高到3 3 .2 % ,并对该合成路线的反应机理进行了初步的探讨。
An improved 3 step way of preparing one of the key antitumor agents 7 ethyl 10 hydro xycamptothecin(SN 38), which consists of ethylation, oxidation and photochemical rearrangement was reported. The possible reaction mechanism was also suggested.
出处
《合成化学》
CAS
CSCD
2000年第2期100-103,共4页
Chinese Journal of Synthetic Chemistry
