摘要
喜树碱早在 196 6年就已经被分离出来 ,由于水溶性差而阻碍了对它的使用。到了 80年代 ,研究者们发现了喜树碱的抗肿瘤机理并再度对它产生了兴趣。在喜树碱的母核上引入一些新的官能团是这一领域中最卓有成效的研究之一 ,许多活性高的喜树碱衍生物相继问世。
Camptothecin was isolated in 1966, but its use was hampered by its poor water solubility. After the new action target of camptothecin was revealed during 1980s, scientists renewed research interest on it. The introduction of certain functional group to the camptothecin nucleus is one of the most fruitful research field during recent years. This article presents the semisynthesis and general total synthesis of several camptothecin derivatives with high potency.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2001年第8期375-380,共6页
Chinese Journal of Pharmaceuticals
