摘要
目的:探讨陕西省商洛市中心医院妇科门诊女性生殖道21种人乳头状瘤病毒(HPV)感染状况及其分布规律。方法:以2010年4月～2011年4月在商洛市区妇科门诊因宫颈疾病而且至少有1年以上性生活史的女性498例为研究对象,采集其阴道宫颈分泌物标本,用凯普医用核酸分子杂交系统(HybriMax)进行21种HPV(6,11,16,18,31,33,35,39,42,43,44,45,51,52,53,56,58,59,66,68,CP8304)基因型的分型检测,分析常见感染亚型和分布规律。结果:研究人群HPV总阳性率为53.01%,常见的10种高危型为HPV16、58、33、52、66、18、31、35、59、53、56;常见的3种低危型为HPV43、11、42。最常见高危型HPV16阳性率分布主要范围在35岁以上,最常见低危型HPV11的阳性率随年龄增加递减。多重感染的比例为31.49%,以二重感染最多见。结论:本地区妇科门诊HPV感染率和多重感染比例均较高,常见感染亚型既符合亚洲人群的分布规律,又有一定的地区性。
Objective： To study the prevalence of 21 genotypes of human papillomavirus（HPV） infection in outpatient department of Center Hospital of Shangluo.Methods：A total of 498 women with cervical disease and with sex life at least for 1 year,who were admitted from April 2010 to April 2011 were selected.Vagina and cervical secretions were collected,and analyzed for 21 HPV genotyps detection（6,11,16,18,31,33,35,39,42,43,44,45,51,52,53,56,58、59,66,68,CP8304） and distribution character.Results： The total positive rate of HPV infection was 53.01%.The 10 most common high-risk genotypes were HPV16,58,33,52,66,18,31,35,59,53 and 56.The 3 most common low-risk genotypes were HPV43,11,42.HPV16 infection was most prevalent in patients aged above 35 years old;while positive rate of HPV11 infection was descended with aging.The total multiple infection rate was 31.49% and two types co-infection were the most common type.Conclusion：The prevalence of HPV infection and multiple infection are high.The common genotype is accordant to the attribution character of the Asia,but also has its own character.
出处
《海南医学院学报》
CAS
2012年第6期842-845,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210203)~~
关键词
乳头状瘤病毒
宫颈癌
导流杂交
基因型
人
商洛市
Papillomavirus
Human
Flow-through hybridzation
Genotype
Cervical cancer
Shangluo
