摘要
目的:检测β-连环蛋白(β-Catenin)和核因子-κB(NF-κB)在宫颈癌组织中的表达情况及临床意义。方法:采用免疫组化染色技术分别检测48例宫颈癌及20例正常宫颈组织中β-Catenin及NF-κB的表达情况。结果:β-Catenin和NF-κB在宫颈癌组织中的阳性表达率分别为68.75%(33/48)和60.42%(29/48),而两者在正常宫颈组织中的阳性表达率分别为5.00%(1/20)和20.00%(4/20),差异有统计学意义(P<0.05)。β-Catenin阳性表达与宫颈癌临床分期(P=0.044)和病理学分级(P=0.008)相关,而NF-κB阳性表达与宫颈癌临床分期(P=0.012)、淋巴结转移(P=0.007)和病理学分级(P=0.000)相关。结论:宫颈癌组织中β-Catenin和NF-κB表达升高且与恶性临床参数相关,β-Catenin和NF-κB可能作为宫颈癌的潜在治疗靶点和预后预测因子。
Objective= To investigate the expression of β-Catenin and NF-κB in cervical cancer tis- sues and its clinical significance. Methods= We detected β-Catenin and NF-κB expression in 48 samples of surgically resected cervical cancer and 20 samples of normal cervix tissues using immunohistochemistry. Results. The positive rate of β-Catenin and NF-κB in cervical cancer tissues （68.75% and 60.42%） were significantly up-regulated compared to those of the normal cervix tissues （5.00% and 20.00%） （x2 = 22. 950, P=0. 000;x2= 9. 232, P= 0. 002）. The positive expression of β-Catenin was significantly correlated with clinical stages （P=0.044） and pathological grades （P=0. 008）, the positive expression of NF-κB was significantly correlated with clinical stages （P=0. 012）, lymph node metastasis （P=0. 007） and patholog- ical grades （P=0. 000）. Conclusion. The expression of β-Catenin and NF-κB increase obviously and are as- sociated with abnormal clinical parameters in cervical cancer. β-Catenin and NF-κB may act as therapeutictargets and prognostic actors in cervical cancer.
出处
《海南医学院学报》
CAS
2013年第12期1647-1649,1652,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210880)~~
