摘要
目的 探索杂交捕获二代（HC-Ⅱ）法检测高危型人乳头瘤病毒（HPV）DNA的意义．方法2003年3—6月在武汉同济医院妇产科采用HC-Ⅱ法检测150例门诊忠者的高危型HPVDNA，以阴道镜辅助活检为金标准，比较该方法的特异性、敏感性、准确性、约登指数及Kappa值。结果高危型HPV阳性率为14．67％，HC—Ⅱ法检测高危型HPVDNA的敏感性、特异性、准确性、阳性预测值、阴性预测值、约登指数及Kappa值依次为：88．89％，91．78％，91．21％，72．73％，97．10％，0．8067，0．7444。假阳性率为6．59％，假阴性率为2．19％。结论HC-Ⅱ法检测高危型HPVDNA阴性预测值高，与金标准有较好的符合率，诊断价值高，为一种很好的早期筛查方法。
Objection To explore the significance of HC- Ⅱ for detecting the high-risk HPV DNA and the early screening of the cervical cancer. Methods A total of 150 cases in the Outpatient Department of Wuhan Tongji Medical College from March to June 2003 were detected with HC- Ⅱ for high-risk HPV DNA ; biopsy assisted by colposcopy was used as golden criterion; the sensitivity （ Se ）, specificity （ Sp）, efficiency （ E ）, positive predictive value （ PPV ）, Youden ＂s index （J） and Kappa value were calculated. Results Positive rate of high-risk HPV was 14. 67%, and the sensitivity,specificity,efficiency,PPV, NPV, Youden＇s index and Kappa value were listed respectively as follows：88.89% ,91.78%, 91.21% ,72. 73% ,97. 10% ,0. 8067,0. 7444. False positive rate was 6. 59% ;false negative rate was 2. 19%. Conclusion There is very high diagnostic value for HPV test and NPV is very high. HC-Ⅱ for HPV test is available for early cervical cancer screening.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2006年第3期181-183,共3页
Chinese Journal of Practical Gynecology and Obstetrics
基金
国家杰出青年基金(30025017)
国家重点基础研究发展规划项目(2002CB513100)
国家自然科学基金面上项目(30271358)
湖北省科技厅攻关项目(2002AA301C54)
关键词
宫颈肿瘤
HC-Ⅱ
人乳头瘤病毒
筛查
Cervical neoplasms
HC- Ⅱ
Human papillomas virus
Screening
