摘要
本工作应用大鼠离体心脏和培养的心肌细胞结合心钠素的放射免疫测定,研究了降钙素基因相关肽对心钠素释放的影响。结果发现,无论在离体心脏或培养的心肌细胞,降钙素基因相关肽均可引起心钠素的释放,并具有剂量效应关系;降钙素基因相关肽对心钠素的释放作用可能不完全依赖于Ca^(2+)的存在。提示心钠素的释放受降钙素基因相关肽的调节。
The effect of calcitonin gene-related peptide (CGRP) on the release of atrial natriuietic factor (ANF) was studied in isolated rat hearts and cultured myocardial cells by means of ANF radioimmu-noassay. It was found CGRP could induce the ANF release from isolated rat hearts and cultured myocardial cells. The effect was in a dose-dependent manner and might be independent of Ca2+. These results reveled that CGRP could stimulate ANF release.
出处
《北京医科大学学报》
CSCD
1989年第5期369-371,共3页
Journal of Peking University(Health Sciences)
关键词
降钙素
基因相关肽
心钠素
心脏
Calcitonin gene-related peptide Atrial natriuretic factor Heart Calcium
