摘要
目的探讨本地区患者泌尿生殖道解脲支原体(Uu)和人型支原体(Mh)感染状况及耐药性变迁,为临床提供最新的流行病学资料及指导临床合理用药。方法采用支原体培养、鉴定、药敏一体化试剂盒对3 236例女性疑似患者泌尿生殖道及宫颈分泌物与231例男性疑似患者泌尿生殖道分泌物进行支原体培养和药敏试验。统计Uu和Mh的感染状况,并分析其耐药性。结果 3 467例患者中支原体阳性1 519例,阳性率为43.8%。主要以Uu感染为主,其中Uu感染的阳性率占79.4%,Mh感染的阳性率占2.0%,Uu与Mh混合感染的阳性率占18.6%。女性患者阳性1 443例,阳性率为44.6%;男性患者阳性76例,阳性率为32.9%。本地区女性患者支原体的感染率明显高于男性,差异有统计学意义(P<0.05)。支原体多发的年龄段是21～40岁,阳性率为79.9%。药敏试验结果显示,Uu、Mh、Uu+Mh三类感染对12种抗菌药物的耐药性不同,但对四环素类的强力霉素、美满霉素敏感性为最高。Uu耐药性最高的是克林霉素和甲砜霉素。Uu+Mh感染时,对阿奇霉素、红霉素、克拉霉素、罗红霉素耐药性最高。Mh耐药最高的是红霉素、阿奇霉素;其次是克拉霉素和罗红霉素。结论临床医生应根据患者临床症状及药敏试验结果合理选用抗生素。
Objective To explore the infection state and the change of drug sensitivity of mycoplasma urealytium（Uu） and mycoplasma hominis in urogenital trac, to provide epidemiology data for rational clinical medication. Methods secretions from urogenital trac and cervix of 3236 suspected female patients and urogenital tract secretions of 231 suspected male patients were cultured and taken drug sensitivity experiment, using culture,identification, drug sensitivity integration kit. The infectious states and drug resistences of Uu and Mh were analyzed. Results In 3 467 cases, 1 519 strains of mycoplasma were positive,and the positive rate was 43.8;,in which the positive rate of Uu and was79.4% ,the positive rate of Mh was 2.0% ,and the positive rate of both Uu and Mh mixed infection was 18.6%. In 1 443 cases of female,the positve rate of infection was 44.6% ,while it was 32.9% for 76 cases of men. The drug resistances of Uu, Mh, Uu＋Mh infections were different for 12 kinds of antibacterial, but the sensitivity was higher to tetracyclines including minocycline and deoxytetracycline. Drug sensitivity of Uu to clindamycin, thiamphenicol were higher. Drug sensitivities of Uu -; Mh to azithromycin, erythromycin, clarithromycin, roxithromycin were higher. Drug sesitivity of Mh to azithromycin and erythromycin were the highest, and then that were clarithromycin and roxithromycin. Most of mycoplasma infections was Uu,and Uu＋Mh infection rate was gradually increasing. The infection rate of myeoplasma in female patients was higher than that in male patients in this area. 21 to 40 was the susceptible age for the infenction of mycoplasma,in which the positive rate was 79.9%. Conclusion Drug sensitivity test can be used for rational clinical medication according to clinical symptoms.
出处
《检验医学与临床》
CAS
2012年第10期1188-1190,1192,共4页
Laboratory Medicine and Clinic
关键词
解脲支原体
人型支原体
感染状况
耐药性
mycoplasma urealytiu
mycoplasma hominis
infection state
drug resistence
