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宫颈癌组织TRAF2表达及其临床意义 被引量：3

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摘要 宫颈癌是常见妇科肿瘤之一,发病率呈上升趋势,如伴有淋巴结转移则严重影响患者的治疗效果和预后.在发展中国家,它是近十年来常见的死亡原因[1].肿瘤坏死因子受体相关因子（tumor necro-sis factor receptor associated factor,TRAF）是肿瘤坏死因子受体（TNFR）的信号传导蛋白,能增强TNF诱导的炎症因子的产生,还能增强TNFR1-TNFR2的协同作用[2],可能与恶性肿瘤的死亡率相关[3].
作者 张怡 叶佩卿 袁秋玮 郭圣为 陈豪 应香岚
机构地区 浙江省台州市中西医结合医院 浙江省台州市肿瘤医院
出处 《浙江中西医结合杂志》 2012年第4期297-299,共3页 Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
关键词 宫颈癌 肿瘤坏死因子受体相关因子 免疫组化
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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  • 2Wicovsky A,Henkler F,Salzmann S. Tumor necrosis factor receptor-associated factor-1 enhances proinflammato-ry TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation[J].Oncogene,2009,(15):1769-1781.
  • 3Panoulas VF,Smith JP,Nightingale P. Association of the TRAF1/C5 locus with increased mortality,particularly from malignancy or sepsis,in patients with rheumatoid ar-thritis[J].Arthritis and Rheumatism,2009,(01):39-46.
  • 4Darvas K,Rosenberger S,Brenner D. Histone deacety-lase inhibitor-induced sensitization to TNFalpha/TRAILmediated apoptosis in cervical carcinoma cells is dependent on HPV oncogene expression[J].International Journal of Cancer,2010,(06):1384-1392.doi:10.1002/ijc.25170.
  • 5刘国成,王泽华.Fas抗原及其配体和TRAIL及其受体在子宫颈癌及其癌前病变组织中的表达[J].中华妇产科杂志,2007,42(8):561-562. 被引量：1
  • 6文华清,耿源源,蔡金凤,王海涛,尹伟,罗应彪,普苹.p16和Ki-67蛋白在宫颈上皮内瘤变中的临床意义[J].临床肿瘤学杂志,2010,15(7):613-616. 被引量：17
  • 7Wang PH,Wan DH,Gu ZH. Litopenaeus vannamei tu-mor necrosis factor receptor-associated factor 6(TRAF6)responds to Vibrio alginolyticus and white spot syndrome vi-rus(WSSV)infection and activates antimicrobial peptide genes[J].Developmental and Comparative Immunology,2011,(01):105-114.
  • 8Lavorgna A,De Filippi R,Formisano S. TNF recep-tor-associated factor 1 is a positive regulator of the NF-kap-paB alternative pathway[J].Molecular Immunology,2009,(16):3278-3282.
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二级参考文献21

  • 1江涛,李隆玉,潘玫,曾四元,乔志强,吴云燕.p16在宫颈癌组织中的表达及其意义[J].实用癌症杂志,2005,20(6):581-583. 被引量：12
  • 2徐海洋,路秀英,马婧,李晓明.肿瘤坏死因子受体及其信号转导蛋白TRAF2在喉癌中的表达[J].吉林大学学报（医学版）,2006,32(2):322-325. 被引量：5
  • 3邓飞,胡新荣.p16与宫颈癌[J].现代肿瘤医学,2006,14(4):500-502. 被引量：11
  • 4CONTI A,NMAMMED AGUENNOZ M,LATORRED,et al.Expression of the tumor necrosis factor receptor-associated factorsl and 2 and regulation of the nuclear factor-KB antiapoptotic activity in human gliomas[J]. J Neurosurg, 2005,103 (5) : 873-881.
  • 5TRANZOLD A,RODER C,SIPOS B,et al.CD95 and TRAF2 Promote invasiveness of pancreatic cancer cells[J]. The FASEB Journal, 2005,19 ( 6 ) : 620-622.
  • 6JACKSON-BERNITSAS DG,ICHIKAMA H,TAKADA Y,et al.Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappa B activation and proliferation in human head and neck squamous cell carcinoma [J].Natl Immunol, 2007,8( 1 ) : 57-63.
  • 7IVANOV V N,FODSTAD Q,RONAI Z.Expression of ring fingerdeleted TRAF2 sensitizes metastatic melanoma cells to apoptosis via up-regulation of p38,TNFα and suppression of NFκB aetrivities [J]. Oncogene, 2001,20(18) :2243-2253.
  • 8Bosch FX, Lorincz A, Muoz N, et al. The causal relation between human papillomavirus and cervical cancer [ J ]. J Clin Pathol, 2002,55:244 - 265.
  • 9Eun JN, Jae W,Hong JW, et al. Expression of the p16^INK4a and Ki-67 in relation tothe grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection [J]. Gynecol Oncol, 2008, 19(3) :162 -168.
  • 10Kalof AN, Cooper K. p16INK4a immunoexpression: surrogate marker of high-risk HPV and high-grede cervical intraepithelial neoplasia[J]. Adv Anat Pathol, 2006, 13 (4) : 190 - 194.

共引文献17

同被引文献15

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二级引证文献15

浙江中西医结合杂志
2012年 第4期

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