摘要
为探讨肝硬化严重程度与血栓素B2 (TXB2 )、6 -酮 -前列腺素F1α(6 -K -PGF1α)的关系 ,了解肝脏受损在肝硬化患者微循环改变中的作用。将 76例肝硬化患者按Child - pugh分级法分为A、B、C组 ,采用放射免疫法测定血TXB2 、6 -K -PGF1α含量。结果 :肝硬化患者TXB2 升高 ,6 -K -PGF1α下降 (P <0 0 5 )。A、B和C组的 6 -K -PGF1α值逐级下降 (P <0 0 5 )。B、C组TXB2 值较A组升高 (P <0 0 5 ) ,B、C组之间无明显差异 (P >0 0 5 )。A、B、C组的TXB2 / 6 -K -PGF1α比值逐级升高 (P <0 0 5 )。结论 :肝硬化患者存在不同程度微循环障碍 ,肝硬化程度越重 ,TXB2 / 6 -K -PGF1α比值越大 ,微循环障碍越重 ,出血倾向越明显 ,预后越差。
WT5”BZ] To investigate the relationship between the cirrhosis in different degrees and TXB 2 and 6-ketone-prostaglaudin F (6-K-PGF 1α ).To learn the effect of the injured liver in the microcycle alteration of the cirrhosis patients. Method: Divide 76 cases of cirrhosis patients into GroupA, GroupB and GroupC according to child-pugh class dividing method. Examine the content of Blood TXB 2、6-K-PGF 1α of GroupA, GroupB and GroupC by radiation immunity method. Result:The rate of 6-K-PGF 1α of GroupA, GroupB and GroupC decreases gradually (P<0 05),the rate of TXB 2/6-K-PGF 1α increases gradually (P<0 05).Conclusion:There is microcycle obstacle in different degrees in cirrhosis patients, the more serious the cirrhosis is, the higher rate of TXB 2/6-K-PGF 1α ,the more serious the microcycle obstacle is, the more obvious the bleeding trend will be and the worse the prognosis will be. [WT5”HZ]
出处
《临床肝胆病杂志》
CAS
北大核心
2000年第1期34-35,38,共3页
Journal of Clinical Hepatology
