摘要
本文对63例不同肺部疾病患者,血浆和尿中6-K-PGF_(1α)及 TXB_2浓度变化进行了测定,并对其在肺部发病中的作用和意义作了讨论。结果显示:17例正常人对照组血浆6-K-PGF_(1α)浓度为178.7±12.0pg/ml((?)±SE,下同)TXB_2为120.9±8.1pg/ml。尿中6-K-PGF_(1α)浓度为517.3±22.9pg/min,TXB_2为213.7±11.4pg/min。不同病因所致肺疾病病理损伤以及功能障碍,均可刺激肺内这两种物质不同程度生成增加,尤以 TXB_2增加为甚。经与对照组作统计学比较分析,均显示有极显著性差异(P<0.01)。尿中以病例组 TXB_2浓度升高较对照组明显,也具有统计学分析意义(P<0.01),6-K-PGF_(1α)的浓度变化不显著(P>0.05)。
Plasma and urine levels of 6-Keto-PGF_(1α)and TXB_2 were assayed in 63 patientswith lung disorders,and the relationship between the levels and the disease occur-ring was studies primarily.The ranges of plasma 6-Keto-PGF_(1α)and TXB_2 contentsin 17 normal controls were 178.8±12.0 pg/ml and 120.9±8.1 pg/ml,respectively,andthose in urine were 517.3±22.9 pg/ml and 213.7±1.4 pg/ml respectively(■±SE).It was found that all the lung diseases,resulting from different causes,could giverise to the various increases of 6-Keto-PGF_(1α)and TXB_2 in lung diseases.Comparedwith the control group,there was apparent statistical significance of plasma 6-Keto-PGF_(1α)and TXB_2 and urine TXB_2 between the patients and the control group(P<0.01),but no difference was observed of the urine 6-Keto-PGF_(1α)levels(P>0.05).
出处
《天津医药》
CAS
1991年第6期346-348,共3页
Tianjin Medical Journal
关键词
肺病
血栓素
前列腺素
诊断
6-Keto-ProstaglandinF_(1α) (6-Keto-PGF_(1α)
thromboxane B_2 (TXB) plasma
urine
