摘要
目的 明确早期应用尼莫地平对ＤＡＩ的安全性和有效性。方法 应用随机双盲法选择颅脑外伤后诊断为ＤＡＩ的患者１０１ 例，随机分为两组，分别采用尼莫地平和安慰剂治疗。结果 外伤后３ 个月，尼莫地平组效果优于对照组，但无显著差异（Ｐ＝ ０．１１） 。而脑血管痉挛亚组及Ⅲ组ＤＡＩ亚组患者中，两组差异显著（ Ｐ＝ ０．０４９，Ｐ＝０ ．０４）。结论 早期应用尼莫地平对ＤＡＩ的治疗是安全有效的。
Based on the characteristic radiological sings and criteria for diffuse axonal injury (DAI),101 consecutive patients with the diagnosis of DAI were enrolled in this randomized,double-blind,placebo-controlled trial,to determine the efficacy and safety of early intervention with nimodipine treatment.Nimodipine proved to be safe and well tolerated.With the advent of TCD sonography we found that there is a higher incidence of cerebral vasospasm in this series (38.2%).Overall,Nimodipine produced a better clinical result than placebo,but there was no statistically significant difference between the two groups on favorable outcome at 3 months after injury ( P =0.11).A trend toward a favorable effect was suggested by the analyses in two small subgroups,either in the patients suffering from clinical Grade Ⅲ DAI ( P =0.04),or in those with the TCD-evidence of cerebral vasospasm during clinical observation ( P =0.049).We postulate that a clinically valuable benefit is possible with nimodipine treatment in DAI patients.However,the effects on outcome should be verified in a larger controlled study.
出处
《苏州医学院学报》
2000年第1期57-58,共2页
Acta Academiae Medicinae Suzhou
