摘要
目的：研究“脑功复得”（一种中药复方制剂） 对脑外伤大鼠学习记忆障碍的治疗作用及作用机理。方法：以液压冲击致颅脑损伤的大鼠为模型，经“脑功复得”治疗后以主动回避试验测定大鼠学习记忆能力，运用光镜行形态学检查，并检测其脑组织中乙酰胆碱、γ－ 氨基丁酸、谷氨酸含量。结果：“脑功复得”治疗组大鼠学习记忆能力提高，脑组织中乙酰胆碱和谷氨酸含量增加，存活的海马神经元增多。结论：“脑功复得”通过提高脑组织中乙酰胆碱和谷氨酸含量及保护海马神经元而发挥其治疗作用。
Objective:To evaluate the effects of Naogongfude (a kind of compound prescripition of Chinese herbs) on brain injury in the Wistar rats.Method:The model was induced by machine of fluid percussion. The ability of learning and memory ,the levels of acetycholine and gamma aminobutyric acid(GABA),and glutamate,and histopathological changes were examined.Result & Conclusion: Naogongfude could improve the ability of learning and memory by increasing the levels of acetycholine and glutamate and protecting the neurons in hippocampal. Author′s address\ Dept. of Neurosurgery,Xinqiao Hospital,Chongqing,400037
出处
《中国康复医学杂志》
CAS
CSCD
2000年第1期29-30,51,共3页
Chinese Journal of Rehabilitation Medicine
