摘要
目的 :探讨细胞凋亡基因Fas和FasL在膀胱癌发病中作用及与肿瘤生物学行为和预后之间关系。方法 :应用免疫组化方法检测 16例正常膀胱粘膜和 72例膀胱移行细胞癌标本中Fas和FasL表达。结果 :膀胱癌中Fas和FasL表达均显著低于正常膀胱粘膜中表达 ;Fas表达与肿瘤分级、分期和复发之间均密切相关 ,但FasL表达与三者之间均无相关性。结论 :Fas和FasL系统异常可能是膀胱癌发生发展过程中免疫逃避的重要因素 ;
Objective:To investigate the roles of pro apoptosis genes Fas and FasL in the pathogenesis of transitional cell cancer of bladder and their relationships with tumor biological behaviors and prognosis. Methods: The immunohistochemistry technique was applied to examine the expression of Fas and FasL in 16 normal bladder mucosa and 72 specimens of transitional cell cancer of bladder. Results:The expressions of Fas and FasL in bladder cancer were significantly lower than those in normal mucosa. The expression of Fas was closely associated with tumor grade, stage and recurrence, while there was no relationship being found for the FasL expression. Conclusions: Fas and FasL system play an important role of immune privilege in the development and progression of bladder cancer; Fas may be a predictor for biological behaviors and prognosis of bladder cancer.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第2期156-158,共3页
Chinese Journal of Cancer
