摘要
抗肿瘤、抗心血管疾病药物白藜芦醇(Resveratrol,Res)由于难溶于水、不稳定而限制了其广泛应用,采用β-环糊精(β-cyclodextrin,β-CD)包裹可克服上述缺陷.研究结果表明随着β-CD浓度增大,Res的水溶性明显增加,Res与β-CD形成包裹物的化学计量比为1∶1.体外实验证实Res/β-CD包裹物可清除具有强氧化与硝化性的过氧亚硝基ONOO-,低温有利于清除反应的进行,CO2的存在减少与ONOO-反应的Res/β-CD包裹物量.
The utilization of anticancer and anticarcinogenesis drug resveratrol （Res） is limited by its poor solubility and stability. The limitation could be overcome by the for- mation of inclusion complexes with β-cyclodextrin （β-CD）. The investigate results show that the solubility of Res increasing with increased β-CD concentration, the stoichiomet- ric ratio of Res with β-CD in the complex is 1 ： 1. The in-vitro experiment conforms that the Res/β-CD inclusion complex can reacts to peroxynitrite, which has strong oxidation and nitration. Lower temperature is benefits the above reaction. The existence of CO2 can reduce the quantity of the Res/β-CD inclusion complex which reacts with peroxynitrite.
出处
《华中师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2012年第2期180-183,189,共5页
Journal of Central China Normal University：Natural Sciences
基金
武汉市科技局对外科技合作与交流计划(201171034319,201070934342)
武汉工程大学青年科学基金项目(Q201104)
武汉工程大学“环境与化工清洁生产实验教学示范中心”创新型实验项目
