摘要
目的 :检测各种肺癌组织中 TGFβ1 的表达情况 ,探讨 TGFβ1 的表达与肺腺癌患者预后的相关性。方法 :免疫组织化学 SABC染色方法。结果 :6 3例女性肺腺癌中 ,TGFβ1 阳性 40例 (6 3.5 % ) ,对照组中 9例肺鳞癌TGFβ1 阳性 1例 (11.1% ) ,15例肺小细胞癌 TGFβ1 仅 1例弱阳性 (6 .7% ) ,2 0例癌旁正常肺组织均为阴性 ,肺腺癌与对照组有显著差异 (P<0 .0 1) ,TGFβ1 阳性患者术后生存期短 ,3a、5 a生存率低 (P<0 .0 1)。结论 :TGFβ1 在女性肺腺癌中过表达 ,且过表达者有较差的预后 ,TGFβ1 可作为肺腺癌预后标志。
Objective:To detect the expression of TGFβ 1 in lung cancer and study its prognostic significance in pulmonary adenocarcinoma.Methods:Immunohistochemical staining was used.Results:TGFβ 1 was positive in 63.5%(40/63) of female pulmonary adenocarcinomas,but only 1/9(11.1%) of lung squamous carcinoma,1/15(6.7%) in small cell lung cancer,0/20(0%) in normal lung tissue. There was significant difference between adenocarcinomas and normal controls (P<0.01). The patients with positive TGFβ 1 had a shortened postoperative survival time and a low 3 and 5 year survival rates also (P<0.01).Conclusion:TGFβ 1 is overexpressed in female pulmonary adenocarcinoma.Patients with TGFβ 1 overepression had a poor prognosis.It is a useful prognostic marker for pulmonary adenocarcinoma.
出处
《肿瘤研究与临床》
CAS
2000年第2期75-77,共3页
Cancer Research and Clinic
关键词
TGFΒ1
肺癌
免疫组织化学
预后
Transforming growth factor β 1(TGFβ 1)
Lung cancer
Immunohistochemistry
Prognosis
