摘要
目的 研究肿瘤坏死因子（Ｔｕｍｏｒ Ｎｅｃｒｏｓｉｓ Ｆａｃｔｏｒα，ＴＮＦα） 对幽门螺杆菌（ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ，Ｈｐ） 感染患者胃泌素（Ｇｓｔｒｉｎ，Ｇａｓ）产生的影响。方法 采用组织培养技术和放射免疫检测技术测定Ｈｐ 感染患者胃窦粘膜培养上清液中Ｇａｓ 的分泌水平及ＴＮＦα对其产生的影响。结果 Ｈｐ 阳性患者的胃窦Ｇａｓ 水平显著高于对照组和Ｈｐ 阴性患者；合并活动性胃炎者Ｈｐ 阳性率和Ｇａｓ 含量均显著高于非活动性胃炎者。ＴＮＦα与Ｈｐ 阳性或Ｈｐ 阴性患者胃窦粘膜共同孵育后可明显增加粘膜Ｇａｓ 含量，并呈量效关系。结论 ＴＮＦα可促使胃窦粘膜Ｇａｓ 的产生，这可能是Ｈｐ 感染导致胃肠粘膜损害的一个环节。
Aim To study the effect of tumor necrosis factor-α(TNF-α)on production of gastrin in patients with H pylori(Hp)infection Method Tissue culture technicue and radioimmunoassay were used to study the changes of antral mucosal gastrin in patients with Hp infection and effeot of TNF-α on production of gastrin Result Antral gastrin content in patients with Hp infection was significantly higher than that in patients without Hp infection and normal controls Gastrin content and Hp positive rate were significantly higher in patients with active gastritis than in those with inactive gastritis Gastrin content was enhanced after antral mucosa of patients with or without Hp infection incubation with TNF-α in vitro,and showing dose-dependent manner Conclusion TNF-α increase production of gastrin may be an important mechanism of gastrin-linked hypothesis in patients with Hp infection
出处
《中国人兽共患病杂志》
CSCD
北大核心
2000年第1期68-69,共2页
Chinese Journal of Zoonoses
关键词
幽门螺杆菌
肿瘤坏死因子
胃泌素
胃粘膜
Helicobacter pylori
Tumor necrosis factor-α
Gastrin
Gastric mucosa
