摘要
目的:了解冠心病患者血清内脏脂肪素(visfatin)水平的变化及其影响因素。方法:观测70例冠心病患者(冠心病组)和18例健康对照(对照组)血清内脏脂肪素水平和其他临床生化指标,分析血清内脏脂肪素的变化及其影响因素。结果:冠心病组血清内脏脂肪素显著高于对照组;合并糖尿病的冠心病患者显著高于没有合并糖代谢异常的患者;冠心病患者血清内脏脂肪素与体重指数、高密度脂蛋白胆固醇(HDL-C)、胰岛素抵抗指数(HOMA-RI)显著正相关,与甘油三酯显著负相关;多因素回归分析显示,胰岛素抵抗指数和体重指数是血清内脏脂肪素的独立影响因素。结论:冠心病患者血清内脏脂肪素水平显著升高,胰岛素抵抗指数和体重指数是其升高的独立影响因素。
Objective： To explore the changes of serum visfatin and its influencing factors in patients with coronary artery disease（CAD）. Methods： Our study included two groups,CAD group,n=70 and Control group,n=18 healthy subjects.Serum visfatin level and other biochemical parameters were examined and compared between two groups. Results：The serum level of visfatin in CAD group was significantly higher than that in Control group.The visfatin level in CAD combined with type 2 diabetes mellitus was much higher than the patients without abnormal glucose metabolism.Visfatin in CAD patients was positively related to body mass index（BMI）,high density lipoprotein cholesterol（HDL-C） and homeostasis model assessment-insulin resistance（HOMA-RI） index.Visfatin was negatively related to triglyceride.Multiple linear regression analysis presented that HOMA-RI and BMI were the independent influencing factors for visfatin in CAD patients. Conclusion：CAD patients have increased serum visfatin.HOMA-RI and BMI are independent influencing factors for visfatin.
出处
《中国循环杂志》
CSCD
北大核心
2012年第2期137-140,共4页
Chinese Circulation Journal
关键词
内脏脂肪素
冠心病
胰岛素抵抗指数
体重指数
Visfatin
Coronary artery disease
Insulin resistance index
Body mass index
