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内脂素与冠心病关系的研究新进展

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摘要 脂肪组织除作为人体能量的储存器官外,其内分泌功能也发挥着重要作用,可以分泌多种脂肪细胞因子,而内脂素（visfatin）就是其中的一种。内脂素具有类胰岛素作用。
作者 陈锐 李海涛 刁增利
机构地区 河北联合大学心内科
出处 《中国循证心血管医学杂志》 2012年第1期80-81,共2页 Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词 内脂 冠心病 内分泌功能 脂肪细胞因子 类胰岛素作用 人体能量 脂肪组织
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献23

  • 1Fukuhara A,Matsuda M,Nishizawa M,et al.Visfatin:a protein se-creted by visceral fat that mimics the effects of insulin[J].Sci-ence,2005,307(5708):426-430.
  • 2Jia SH,LI Y,Parodo J,et al.Pre-B cell colony-enhancing factor in-hibits neutrophi1 apoptosis in experimental inflammation and clini-cal sepsis[J].J Clin livest,2004,113(9):1318-1327.
  • 3Ognjanovie S,Bao S,Yamamoto SY,et al.Genomieorganization ofthe gene coding for human pre-B-cell colony enhancing factor andexpressionin in human fetal membranes[J].J Mol Endoerinol,2001,26(2):107-117.
  • 4Samal B,Sun Y,Steams G,et al.Cloning and characterization ofthe cDNA eneoding a novel human pre-B-cell colony-enhaneing fac-tor[J].Mol Cell Biol,1994,14(2):1431-1437.
  • 5Kraliseh S,Klein J,Lossner U,et al.Interleukin-6 is a negativeregulator of visfatin gene expression in 3T3-L1 adipocytes[J].AmJ Physio Endoerinol Metab,2005,289(4):E586-E590.
  • 6Haider DG,sehindlerK,Sehaller G,et al.Inereased plasma visfatinconcentrations in Morbidly obese subjects are reduced after gastricbanding[J].J Clin Endoerinol Metab,2006,91(4):1578-1581.
  • 7Berndt J,Kloting N,Kraliseh S,et al.Plasma visfatin coneentra-tions and fat depot-sPeeific mRNA exp ression in humans[J].Dia-betes,2005,54(10):2911-2916.
  • 8Chen MP,Chung FM,Chang DM,et al.Elevated Plasma level ofvisfatin/Pre-Beell colony-enhaneing factor in patients with type 2diabetes mellitus[J].J Clin Endoerinol Metab,2006,91(1):295-299.
  • 9Kloting N,Kloting I.Visfatin:gene exp ression in isolated adipo-eytes and sequenee Analysis in obes WOKW rats compared withlean control rats[J].Bioehem BioPhys Res Commun,2005,332(4):1070-1072.
  • 10Moschen AR,Kaser A,Enrich B,et al.Visfatin,an adipocytokinewith Proinflammatory and immunomodulating properties[J].J Im-munol,2007,178(3):1748-1758.

二级参考文献15

  • 1张代娟,武少杰,刘同美,田华,王一鹏,段文卓,叶笃筠.青心酮对RAW264.7细胞可溶性Toll样受体4表达及炎症相关因子的影响[J].中国临床康复,2006,10(11):120-122. 被引量：6
  • 2Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science, 2005 , 307(5708) : 426-430.
  • 3Moschen AR, Kaser A, Enrich B, et al. Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. J Immunol, 2007 , 178 (3): 1748-1758.
  • 4Dahl TB, Yndestad A, Skjelland M, etal. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization. Circulation,2007,115(8) :972-980.
  • 5Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol., 1983;51 (3) :606.
  • 6Adya R, Tan BK, Chen J, et al. Nuclear faetor-kappaB induetion by visfatin in human vaseular endothelial cells: its role in MMP-2/9 production and activation. Diabetes Care,2008,31 (4):758-760.
  • 7Haider DG, Holzer G, Sehaller G, et al. The adipokine visfatin is markedly elevated in obese children. J Pediatr Gastroenterol Nutr,2006;43(4) :548-549.
  • 8Tilg H, Mosehen AR. Role of adiponectin and PBEF/visfatin as regulators of inflammation: involvement in obesity-associated diseases. Clin Sci (Lond) ,2008, 114(4) :275-288.
  • 9Adya R, Tan BK, Punn A, et al. Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatininduced angiogenesis. Cardiovasc Res, 2008 , 78 (2) : 356-365.
  • 10Kim SR, Bae YH, IMe SK, et al. Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells. Biochim Biophys Acta,2008;1783 (5) :886-895.

共引文献19

中国循证心血管医学杂志
2012年 第1期

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