摘要
目的:考察麻黄与老鹳草配伍前后主要活性成分盐酸麻黄碱和没食子酸提出率的变化,探讨两药配伍使用的增效作用机制。方法:以盐酸麻黄碱和没食子酸为指标,HPLC测定含量,采用正交试验法优选配伍前后提取工艺。结果:麻黄配伍后盐酸麻黄碱的提出率分别为5.136,5.485 mg·g-1,老鹳草配伍前后没食子酸的提出率分别为1.352,1.564 mg·g-1。结论:麻黄和老鹳草配伍前后盐酸麻黄碱、没食子酸提出率均增加,为两药配伍使用增效作用提供依据。
Objective：To investigate change of extract rate of main active ingredient before and after compatibility of Ephedrae sinica and Erodium stephanianum,such as ephedrina hydrochloridum and galic acid,and explore synergistic effect mechanism when compatibility of this two medicines.Method： Taking the contents of ephedrina hydrochloridum and galic acid as indexes,before and after compatibility,optimum extraction technology was optimized by orthogonal test and HPLC was adopted to determine the content of each index components.Result： Before and after compatibility,Extract rates of ephedrina hydrochloridum from E.sinica were 5.136,5.485 mg·g-1,extract rates of galic acid from E.stephanianum were 1.352,1.564 mg·g-1.Conclusion： After compatibility of E.sinica and E.Stephanianum,extract rate of ephedrina hydrochloridum and galic acid increased respectively.It provided basis for synergistic effect when two medicines were companied with each other.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第8期50-54,共5页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
麻黄
老鹳草
正交试验
盐酸麻黄碱
没食子酸
Ephedrae sinica
Erodium stephanianum
orthogonal test
ephedrina hydrochloridum
galic acid
