摘要
目的:应用星点设计-效应面法优化地锦草总黄酮结肠定位片的处方。方法:以果胶、L-HPC用量及包衣增重为考察因素,以2,6,9 h地锦草总黄酮中有效成分槲皮素的累积释放度为评价指标,采用Design-expert软件对试验数据进行多元线性模型和二次多项式模型拟合,得出最佳数学模型,绘制效应图和等高线图,通过重叠等高线图得到最优处方并进行验证。结果:二次多项式模型相关系数优于多元线性模型,为最终拟合模型;最佳处方的各时间点累计释放度的实际值和预测值接近,相对偏差绝对值<5%。结论:通过星点设计-效应面法建立的模型预测性良好,可用于对地锦草总黄酮结肠定位片处方的优化。
Objective：To optimize formulations of total flavonoids from Euphorbia humifusa（EFCTT） by central composite design-response surface method.Method： With the amount of lactose and L-HPC,coating weight gain as factors,with cumulative release at 2,6,9 h of quercetin from total flavonoids as index,Design-Expert software was used to fit multivariate linear models and quadratic multinomial models for experimental data,and obtained optimum mathematical model,drew effect diagram and contour maps,optimum prescription was obtained by overlapping contour maps and verified.Result： The correlation coefficient of quadratic multinomial models was better than multivariate linear models,and it was the final fitting model;Cumulative release in four time point of optimum prescription was close between observed value and predicted value with relative deviation was less than 5%.Conclusion： Model established by central composite design-response surface method had good predictive,it could be used to optimize prescription of EFCTT.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第8期42-45,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
地锦草总黄酮
结肠定位片
星点设计-效应面法
重叠等高线
高效液相色谱法
total flavonoids from Euphorbia humifusa
colon-targeted tablets
central composite design-response surface methodology
overlapping contour
HPLC
