摘要
目的研究膀胱尿路上皮癌（BUC）组织中趋化因子受体CCR7蛋白的表达情况，探讨CCR7蛋白表达与临床病理特征的相关性以及对BUC患者预后的影响。方法采用免疫组化染色法检测2006年1月至2009年12月57例因膀胱肿瘤行开放式根治性膀胱切除术的BUC组织以及10例正常膀胱组织中CCR7蛋白表达情况。分析CCR7蛋白表达与肿瘤分期、分级、大小、数量、发病次数、患者年龄、性别以及淋巴结转移之间的关系，分析BUC患者发生淋巴结转移的影响因素，并研究BUC患者预后的影响因素。结果57例BUC组织中CCR7蛋白表达阳性率为82．5％（47／57），高表达率为45．6％（26／57）；正常膀胱组织中CCR7蛋白表达阳性率为20．0％，且均为低表达；组间差异有统计学意义（P〈0．05）。淋巴结阳性组CCR7蛋白高表达率为68．2％（15／22），淋巴结阴性组为31．4％（11／35），差异有统计学意义（P〈0．01）。CCR7蛋白表达与肿瘤分期、分级、大小、数量等其他临床病理特征无明显相关性。CCR7蛋白表达水平、肿瘤病理分期、分级与淋巴结转移显著相关（P〈0．05）；仅CCR7是淋巴结转移的独立影响因素。CCR7蛋白高表达组的术后无复发生存率明显低于低表达组（P〈0．05）。结论CCR7蛋白在BUC组织中表达异常增加，可能是预测淋巴结转移的重要指标。CCR7蛋白表达水平可能影响BUC患者的预后。
Objective To explore the CCR7 expression status in bladder urothelial carcinoma （BUC） and the relationship between CCR7 expression and lymph node metastasis, and analyze the impact of CCR7 expression on prognosis. Methods The expression levels of CCR7 in 57 BUC tissues and 10 nor- mal bladder tissues were estimated by immunohistochemistry technique, and the correlation between CCR7 with lymph node metastasis, tumor stage, grade, number, size, relapse or not, and patients＇ age/sex of BUC was analyzed. The influence factors of lymph node metastasis were tested, and so were the influence factors of prognosis. Results The positive rate of CCR7 expression among 57 patients was 82.5% （47/ 57） （high expression rate was 45.6% ） , which was higher than that in normal bladder tissue （20.0% , all were low expression, P 〈 0.05）. The high expression rate of CCR7 in lymph node metastasis group was 68.2% （15/22）, higher than that in none lymph node metastasis group （31.4%, 11/35, P 〈 0.01 ）. The expression level of CCR7 had no significant correlation with tumor stage, grade or other parameters. CCR7 expression, tumor stage and tumor grade were correlated with lymph node status （ P 〈 0.05） , but only the first was an independent one. High CCR7 expression had a significant link with low relapse free survival （P 〈 0.05）. Conclusion The expression of CCR7 was highly expressed in BUC, which may be a posi- tive independent influence factor of lymph node metastasis, and a predictor of poor prognosis.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2013年第5期352-356,共5页
Chinese Journal of Urology
