摘要
采用小鼠ＣＣｌ４中毒性肝纤维化模型，观察两组中药复方对肝纤维化超微结构的影响。结果表明，ＣＣｌ４模型组肝细胞脂肪变性严重，大量胶原纤维增生；二参泽术汤预防组肝细胞病变轻微，光纤维形成；二参泽术汤治疗组部分肝细胞脂变，未见纤维增生，病史较模型组显著减轻；丹参桃芎汤预防组、治疗组病变相似，肝细胞脂变严重，形成大量胶原纤维。提示二参泽术汤有保护肝细胞、防治肝纤维化的作用，而丹参桃芎汤效果不理想。
In order to Study the effects of two Chinese traditional medicine decoctions, Ershenzezhutang (ESZST) and Danshentaoxiongtang (DSTXT) on preventing and treating hepatic fibrosis, a hepatic fibrosis model of mouse by using carbon tetrachloride toxicant(CCl4) was established.The ultrastructure of liver tissue was observed under transmission electronic microscope. It was found that the model group had hepatocytes lipid-changed severely and many collagen fibers sedimentated; the preventive group of ESZST had little pathologic change,and no collagen fibers was found;the treatmental group of ESZST had a few hepatocytes lipid-changed severely and many collagen fibers sedimentated. Results show that ESZST has a effect on protecting hepatocytes and relieving hepatic fibrosis but DSTX has no this effect.
出处
《中国中医药科技》
CAS
2000年第3期139-140,共2页
Chinese Journal of Traditional Medical Science and Technology
