摘要
目的:观察王氏抗肝纤方对肝纤维化的治疗作用及其作用机制。方法:采用二甲基亚硝胺诱导肝纤维化模型,从组织学改变观察王氏抗肝纤方的疗效,以γ干扰素及膈下退瘀汤作为对照组。结果:王氏抗肝纤方对肝歼堆化大鼠能显著降低血清ALT、AST及肝组织Hyp含重,减少肝组织中ColⅠ、ColⅣ的沉积和a-SMA的表达,提高肝组织间质胶原酶活性。其作用同γ干扰素而明显优于膈下逐瘀汤。结论:王氏抗肝纤方具有较好的抗肝纤维化作用,能抑制胶原纤维的形成,并通过提高肝组织间质胶原酶活性而促进胶原的降解。
Aim: To study the pharmacological actions of Wang's Anti-fibrosis decoction on experimental liver fibrosis in Rats. Methods t Using dimethylnitrosamine (DMN) produced rat model of liver fibrosis. observed therapeutic effect of Wang's anti-fibrosis decoction on alteration of histology. Interferon gamma (IFN-T) and Gexiazhuyu decoction were used in control group. Results: Wang's anti-fibrosis decoction lowered the serum level of ALT, AST and Hyp in liver stissue. Image analysis indicated significant attenuation of collagen type I , IV and a-smooth muscle actin (a-SMA) content after Wang's anti-fibrosis decoction treatment. The hepatic interstitial collagenase activity was raised. No obvious different from IFN-T group but was better than Gexiazhuyu decoction group. Conclusions: These results suggested that Wang's anti-fibrosis decoction have showed better anti-hepatofibrosis effect in experimental rats. The proliferation of collagenous fibers was restrained and the decomposition was impelled by raise the interstitial collagenase activity.
出处
《中西医结合肝病杂志》
CAS
2000年第3期19-21,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
肝纤维化
王氏抗肝纤方
间质胶原酶活性
Liver Fibrosis Wang's Anti-fibrosis Decoction Pathology Interstitial Collagenase Activity
