摘要
目的研究人工关节置换术后感染患者病原菌分布及其耐药情况,为临床合理选择抗菌药物提供依据。方法对我院2010年人工关节置换术后感染患者80株病原菌采用常规方法进行鉴定,除万古霉素药敏试验采用E-TEST外,其他药敏试验采用K-B法。结果感染比例最高病原菌为凝固酶阴性葡萄球菌(CNS)(38.75%),其次为金黄色葡萄球菌(18.75%)。青霉素、红霉素和头孢西丁对CNS耐药率分别为77.42%、74.19%和54.84%,对金黄色葡萄球耐药率分别为100%、73.33%和33.33%;万古霉素和力奈唑烷对CNS和金黄色葡萄球菌敏感率都为100%。结论人工关节置换术后感染前两位病原菌分别是CNS和金黄色葡萄球菌,两者对青霉素类和大环内酯类药物有很高的耐药率,但未检测出对万古霉素和力奈唑烷耐药的菌株。
Objective To provide the evidence for the rational use of antibiotics by studying the distribution and drug resistance of pathogens in patients with infection after artificial joint replacement.Methods Pathogens from 80 patients with infection admitted to our hospital in 2010 were routinely identified after artificial joint replacement.Sensitivity of drugs was tested with the K-B method but that of vancomycin was detected by E-TEST.Results The infection rate of coagulase-negative staphylococci（CNS） was the highest（38.75%） followed by S.aureus（18.75%）.The resistance rate of CNS and S.aureus to penicillin,erythromycin,cefoxitin was 77.42%,74.19%,54.84% and 100%,73.33%,33.33%,respectively.The sensitivity of CNS and S.aureus to vancomycin and linezolid was 100%.Conclusion The first two pathogens in patients with infection after artificial joint replacement are CNS and S.aureus which are highly resistant to penicillin and macrolides but not resistant to vancomycin and linezolid.
出处
《军医进修学院学报》
CAS
2012年第4期335-336,386,共3页
Academic Journal of Pla Postgraduate Medical School
基金
首都医学发展科研基金资助(2009-1023)~~
