摘要
目的 观察 FK— 5 0 6抑制全角膜移植术 (包括带环形巩膜瓣的全角膜移植术 )后免疫排斥反应的临床疗效。方法 对 76例 (76只眼 )全角膜移植术患者按随机原则分试验组 (FK— 5 0 6组 )及对照组 (Cs A组 )各 38例(38只眼 ) ,观察术后不同时期角膜移植术后角膜免疫排斥反应的发生率 ,平均随访时间 6个月。结果 全角膜移植术后 ,局部应用 FK— 5 0 6可有效抑制新生血管的发生 ;随访期内 ,治疗组 (FK— 5 0 6组 )移植片排斥反应发生率为6 8.4% ,而对照组 (Cs A组 )的排斥反应发生率为 92 .1% (u检验 ,P<0 .0 1) ,两组具有显著差异。结论 局部应用FK— 5 0 6可有效抑制高危角膜移植术后免疫排斥反应的发生 。
Objective To observe clinical effects of FK-506 suppressing immunologic rejection after total corneal transplantation(TCT) and TCT with circle lamellar scler (CST).Methods The 76 patients (76 eyes) with TCT were divided randomly into the experimental group treated by Kk-506 eyedrops and the control group treated by CsA eyedrops,with 38 patients (38 eyes) each.The the average 6 follow-up months,the incidence rates of postoperation graft rejection were observed.Results After TCT the local applying of FK-506 could suppress effectively neovascularization.In the follow-up period,the rejection rates of the experimental group(FK-506) and the control group(CsA) were 68.4% and 92.1% respectively,with significant difference (u examination, P <0 01) Conclusion The local applying of FK-506 suppressed effectively postoperation immunologic rejection of high-risk keratoplasy and elongated the graft transparent duration after TCT.
出处
《临床眼科杂志》
2000年第2期84-86,共3页
Journal of Clinical Ophthalmology
基金
卫生部课题基金! (96 112 2 )
广东省自然科学基金!(96 0 14 5 )
广东省重点科技攻关项目! (96 2 2 0 5 0 0 4)
