摘要
1例74岁男性患者,因糖尿病、脑供血不足给予胰岛素、三七皂苷、奥拉西坦治疗。第3天因阻塞性肺炎加用头孢地嗪钠1.0 g溶于0.9%氯化钠注射液100 ml,2次/d静脉滴注。联合用药第5天,患者咳嗽、咯痰好转,但躯干及四肢皮肤出现皮疹,体温39.0℃。停用头孢地嗪钠、三七皂苷和奥拉西坦,并给予抗过敏和对症处理。停药后1 d体温降至37.8℃,皮疹颜色较前变浅,但头面部出现新发皮疹。肝功能检查示天冬氨酸转氨酶(AST)596 U/L、丙氨酸转氨酶(ALT)768 U/L、血清总胆红素(TBil)39.1μmol/L。经过7 d抗过敏、护肝治疗,患者全身皮疹基本消退,肝功能逐渐恢复正常(AST 56 U/L,ALT 25 U/L,TBil12.5μmol/L)。其后未再使用头孢地嗪钠,而再次应用三七皂苷和奥拉西坦后未出现上述不良反应。
A 74-year-old male patient received insulin, arasaponin, and oxiracetam for diabetes mellitus and cerebral circulation insufficiency. On day 3 ,an IV infusion of cefodizirne sodium 1.0 g in 0.9% sodium chloride solution 100 ml twice daily was added to his regimen for pneumonia. On day 5 of combination therapy, his cough and expectoration improved while the patient experienced eruption on trunk and limbs with a high temperature of 39 ℃. Cefodizime sodium, arasaponin, and oxiracetam were all stopped and he was given anti-allergic and other symptomatic therapy. One day after drug discontinuation, his temperature decreased to 37.8 ℃ and the eruption was lighter in color than before. However, new eruption appeared on his head and face. Liver function examinations showed an aspartate aminotransferase （AST） level of 596 U/L, an alanine aminotransferase （ALT） level of 768 U/L, and a total bilirubin （TBil） level of 39.1 μmol/L. After receiving a 7-day anti-allergic and liver protective treatment, his generalized eruption vanished basically and liver function gradually return to normal （AST 56 U/L, ALT 25 U/L, and TBil 12.5 μmol/L）. Cefodizime sodium was not administered again and the above-mentioned adverse reactions did not recur after readministration of arasaponin and oxiracetam.
出处
《药物不良反应杂志》
2012年第1期54-56,共3页
Adverse Drug Reactions Journal
关键词
头孢地嗪钠
药疹
肝疾病
cefodizime sodium
drug eruption
liver diseases
