摘要
目的：了解胰腺癌及其癌旁组织的ｐ５３蛋白表达，并分析其临床意义。方法：作者对３６例胰腺导管癌、２５例胰腺癌旁组织、１０例慢性胰腺炎和１２例正常胰腺组织石蜡标本进行ｐ５３单抗的免疫组化染色。结果：３６例胰腺癌和２５例癌旁组织中呈ｐ５３蛋白阳性染色分别为２１例（５８％）和１１例（４４％），且其阳性率间有显著相关性。（Ｐ＜０．０１）。而慢性胰腺炎和正常胰腺组织均未见ｐ５３蛋白阳性染色，与胰腺癌和癌旁组织ｐ５３阳性率间均有显著差异（Ｐ＜０．０１）。不同临床分期及组织学分型胰腺癌，ｐ５３蛋白阳性染色率间无显著差异。结论：ｐ５３蛋白的表达与胰腺癌的发生有关；胰腺癌旁组织中某些细胞呈ｐ５３阳性染色，这些细胞可能较易发生癌变，使胰腺癌呈多中心性发生。
Purpose: In order to explore the expression of p53 protein in pancreatic adenocarcinomas and their adjacent tissues. Methods: We used immunohistochemical method to examine formalin-fixed paraffinembedded samples of 36 pancreatic adenocarcinomas, 25 nommalignant peri-tumoral tissues, 10 chronic pancreatitis and 12 normal pancreatic tissues for overexpression of the p53 gene product. Results: Specific nuclear staining for the p53 protein was identified in 21 out of 36 carcinomas and 11 out of 25 nonmalignant peri-tumoral tissues. The positive rate of p53 was significantly higher in cancer or adjacent tissues than chronic pancreatitis or normal panreatic tissues (P<0.01). Besides, no significant difference of p53 staining was found among different clinical stages and histologic differentiation. Conclusion: p53 protein is involved in the carcinogenesis if pancreatic adenocarcinomas. In addition, the nonmalignant peritumoral tissues staining positively for p53 protein might reveal their susceptibility of tumorogenesis.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1998年第2期140-142,F003,共4页
Chinese Journal of Cancer
