摘要
目的:探讨新发Graves病患者抗甲状腺药物治疗2月前后怒、焦虑、抑郁情绪及与3种情绪密切联系的5-羟色胺(5-HT)、多巴胺(DA)的血清水平变化,为临床治疗Graves病伴发的情绪障碍提供临床及流行病学依据。方法:在山东大学中心医院、泰安市中心医院内分泌科门诊调查122例新发Graves病患者,现场填写《自评焦虑量表(SAS)》、《自评抑郁量表(SDS)》、《STAX-2量表》,采集血样并检测血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、TSH受体抗体(TRAb)、5-HT、DA等的水平,抗甲状腺药物常规治疗2月后门诊复查时再次填写上述3表并采集血样检测上述指标。采用成组设计资料的t检验,应用SPSS19.0进行统计。结果:随访治疗2月后,因各种原因仅87名患者完成随访。对治疗前后两组病人的上述各项指标进行分析比较发现,治疗后,怒成分中怒控制(AC-I)、控制怒的发出(AC-O)分值升高;焦虑、抑郁情绪分值下降;FT3、FT4下降、TSH上升;血清5-HT升高、血清DA水平下降(P<0.05,P<0.01)。结论:怒、焦虑、抑郁等负性情绪常伴随Graves病的发病而出现过度表现,抗甲状腺药物治疗后怒控制能力提高;伴随的怒情绪于治疗后易于控制。焦虑、抑郁情绪缓解。5-HT、DA等呈现一致性变化。
Objectives： To explore the changes of anger,anxiety,depression and 5-HT,DA serum levels of newly-diagnosed Graves＇disease after treatment with anti-thyroid drugs.Methods： 122 out-patients newly-diagnosed Graves＇disease in endocrine department of Jinan Central hospital and Taian Central hospital were investigated and asked to fill in Self rating Anxiety Scale（SAS）,Self rating Depression Scale（SDS）,and State-Trait Anger Expression Inventory 2（STAX-2）.Collected blood samples for detecting FT3,FT4,TSH,TRAb,5-HT and DA.After treatment with anti-thyroid drugs for two months,these patients filled those scales again and gave their blood samples.Data was determined using group-designed t test by SPSS 11.5.Results： Only 87 of 122 patients completed treatment for two months.After treatment,the scores of AC-I,AC-O increased for anger control,both the depression and anxiety scores decreased significantly.5-HT and TSH increased while DA,FT3,FT4 decreased（P0.05,P0.01）.Conclusion： For anger,anxiety,depression of newly diagnosed GD,anti-thyroid drugs may be helpful for their disorder mood.For these patients,except serious emotional disorders,drugs for regulating emotions are not needed.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2012年第4期908-911,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家重点基础研究发展计划项目(973计划)(No.2006CB504804)~~
