摘要
目的对初诊弥漫性甲状腺肿伴甲状腺功能亢进症即Graves(GD)疾病患者并发抑郁、焦虑症状进行分析,并探讨其危险因素。方法收集2008年4～6月就诊于宁夏医学院附属医院内分泌门诊初诊为Graves病患者90人,采用Zung抑郁自评量表(SDS)及焦虑自评量表(SAS)对其抑郁焦虑症状进行评估,记录患者性别、年龄、文化程度、职业、经济状况、家族史、婚姻等一般情况,并检测患者甲状腺功能。采用Logistic回归分析确定抑郁焦虑状态的危险因素。结果初诊Grave病患者抑郁、焦虑状态发生率分别为61.1%(55/90)、52.2%(47/90),抑郁和焦虑共存的发生率为41.1%(37/90)。TT3水平和文化程度是初诊Graves病合并焦虑的危险因素,TT3水平、职业(分为脑力和体力劳动)、年龄是初诊Graves病合并抑郁的危险因素。结论GD抑郁焦虑患病率高,TT3水平越高、文化程度越低越易并发焦虑;TT3水平越高、从事脑力劳动的年轻患者越易并发抑郁。
Objective To explore the characteristic distribution and risk factors of major depression and anxiety in patients with diffuse toxic goiter accompanied by hyperthyroidism for the first diagnose, i.e. Graves＇ disease. Methods We collected the data of 90 patients with Graves＂ disease who were first diagnosed in out-patient department of affiliated hospital of Ningxia Medical College from April, 2008 to June, 2008. Their depression and anxiety status were assessed using the Zung depression scale and the Zung anxiety scale. The general information was recorded, such as gender, age, education level, occupation, economic status, family history and marriage. The risk factors of depression and anxiety status were determined using multinomial logistic regression in GD patients. Results Among 90 GD patients, 55 people （61.1%） had major depression, and the rate of anxiety was 52.2%. Among the GD patients, 37 people had both anxiety and depression, with the rate of 41.1%. The risk factors for patients with Graves＇ disease for the first diagnose in combination with major depression were age, occupation （mental work or physical work） and the level of TT3. The risk factors for patients with Graves＇ disease for the first diagnose in combination with major anxiety were the level of TT3 and education. Conclusions The rate of GD with depression and anxiety is high. The GD patients, who are young, have higher level of TT3 and use more brain, are easy to be in depression. The GD patients who have bad education and higher lever of TT3 are easy to be in anxiety.
出处
《神经疾病与精神卫生》
2008年第4期291-293,共3页
Journal of Neuroscience and Mental Health
关键词
GD
抑郁
焦虑
Graves disease （GD）
Major depression
Major anxiety
