摘要
目的考察适合盐酸椒苯酮胺冻干制剂的辅料。方法配制含不同质量分数辅料的盐酸椒苯酮胺溶液(2 mg/mL,5 mL/支),包括甘露醇、蔗糖、乳糖、甘氨酸、右旋糖酐,经冻干后观察制剂的外观、含量、澄清度、颜色、pH等特性,以筛选盐酸椒苯酮胺冻干制剂的辅料。结果冻干制剂复溶后,甘露醇组出现乳浊;3%～5%蔗糖组色偏深;甘氨酸组乳浊并色偏深;乳糖和右旋糖酐组的外观、含量、澄清度、颜色均较佳。结论优选乳糖作为盐酸椒苯酮胺冻干制剂的辅料。
Objective To investigate the adjuvant of piperphentonamine hydrochloride freeze-dried preparation. Methods The different adjuvants including mannitol, cane sugar, lactose, glycine and dextran were optimized by dispensing piperphentonamine hydrochloride liquids with apperanee, content, clarity, color and pH. Results The mannitol groups show opacifying. 3% -5% cane sugar groups show deep color. The glycine groups show opacifying and deep color. The lactose and dextran groups show qualified shape, content, clarity and color. Conclusions Lactose is a qualified adjuvant of piperphentonamine hydroehloride freeze-dried preparation.
出处
《广东药学院学报》
CAS
2012年第1期13-16,共4页
Academic Journal of Guangdong College of Pharmacy
基金
国家"十二五"重大新药创制科技重大专项(2011ZX091011-003)
科技部创新基金(10C26214412687)
广东省中国科学院全面战略合作项目(2009B091300065)
广州市专利技术产业化示范项目(200903)
广州市重大专项课题(2008A1-E4161)
关键词
盐酸椒苯酮胺
甘露醇
乳糖
冻干制剂
piperphentonamine hydroehloride
mannitol
lactose
freeze-dried preparation
