摘要
目的:比较两种盐酸椒苯酮胺含量测定的方法。方法:采用HPLC法和非水碱量法,在线性、精密度、稳定性以及专属性方面进行方法学确证,并比较二者测定3批盐酸椒苯酮胺含量的差异。结果:两种方法在线性、精密度、稳定性以及专属性方面均符合要求,定量限为0.02μg·ml^(-1)。结论:HPLC法与非水碱量法的测定结果一致,均可用于盐酸椒苯酮胺的含量测定。
Objective： To compare HPLC and Alkalimetry in content detection of Injection Piperphentonamine Hydroehloride. Method： HPLC and Alkalimetry methods was compared in linearity, precision, stability and specificity, and the contents of 3 batches of Injection Piperphentonamine Hydroehloride were also compared determined by the two methods. Result： The two methods are all fit the bill in linearity ,precision and stability, the limit of quantitation are 0.02μg · ml^-1. specificity Conclusion ：The results of HPLC and Alkalimetry are concordant, and all can be used to detect the content of Injection Piperphentonamine Hydrochloride.
出处
《中国药师》
CAS
2012年第2期219-221,共3页
China Pharmacist
基金
国家"十二五"新药创制科技重大专项(No:2011ZX091011-003)
科技部创新基金项目(No:10C26214412687)
广东省中国科学院全面战略合作项目(No:2009B091300065)
广州市专利技术产业化示范项目(No:200903)
广州市重大专项(No:2008A1-E4161)
