期刊文献+

激素替代疗法治疗绝经期症状临床探讨分析 被引量:2

暂未订购
导出
摘要 目的探讨激素替代治疗(HRT)的安全性。方法采用HRT治疗绝经期妇女51例,有子宫者应用尼尔雌醇2mg口服,每月2次,每3个月加用安宫黄体酮6mg口服,每天1次,连用10d;子宫切除术后者单用尼尔雌醇,每半年进行妇科、乳腺B型超声检查,每年进行血生化系列检查。结果用药后高密度脂蛋白胆固醇(HDL-C)水平上升(P<0.05),低密度脂蛋白胆固醇(LDL-C)水平下降(P<0.05)。子宫出血例数以绝经初期为多,绝经时间越短子宫出血率越高。用药后子宫内膜厚度和乳腺增生程度无明显增加。结论定期对接受HRT的妇女进行检查和评价,使HRT的应用更为安全有效。
作者 张晓燕
出处 《临床合理用药杂志》 2012年第10期65-66,共2页 Chinese Journal of Clinical Rational Drug Use
  • 相关文献

参考文献3

  • 1徐苓.性激素替代治疗[J].中国实用妇科与产科杂志,2004,20(8):449-450. 被引量:19
  • 2Palin SI,Kumar S,Stuedee DW,et al.Hormone replacement therapy for menopausal women with diabetes[J].Diab Obesity Metab,2001,3(3):187-192.
  • 3Ahmed M,Raafat PD,Lorne J,et al.Proliferative effects of combination estrogen and progesterone replacement therapy on the normal postmenopausal mammary gland in a murine model[J].Am J Obstet Gynecol,2001,184(2):340-349.

二级参考文献13

  • 1徐苓,赵珩,葛秦生.围绝经期的流行病学调查[J].生殖医学杂志,1993,2(1):23-27. 被引量:105
  • 2卫生部继续医学教育委员会.女性生殖内分泌性激素补充疗法[M].北京:北京医科大学、中国协和医科大学联合出版社,1999.84-90.
  • 3Hulley SB,Grady D.The WHI estrogen-alone trial-do things look any better?JAMA,2004,291(14):1769-1771
  • 4Hully S,Grady D,Bush T,et al.For the Heart and Estrogen/Progestin Replacement Study Research Group.Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women.JAMA,1998,280:605-613
  • 5Rossouw JE,Anderson GL,Prentice RL,et al.Risks and benefits of estrogen plus progestin in healthy postmenopausal women:principal results from the Women's Health Initiative randomized controlled trial.JAMA,2002,288:321-333
  • 6Manson JE,Hsia J,Johnson KC,et al.Estrogen plus progestin and the risk of coronary heart disease.N Eng J Med,2003,349:523-534
  • 7Chlebowski RT,Hendrix SL,Langer RD,et al.Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women the Women's Health Initiative randomized controlled trial.J Am Med Assoc,2003,238:3243-3253
  • 8Million Women Study Collaborators.Breast cancer and hormone-replacement therapy in the Million Women Study.Lancet,2003,362:419-427
  • 9International Menopause Society.Guidelines for the hormone treatment of women in the menopausal transition and beyond.Climacteric,2004,7:8-11
  • 10The Women's Health Initiative Steering Committee.Effects of conjugated equine estrogen in postmenopausal women with hysteractomy.The Women's Health Initiative randomized controlled trial.JAMA,2004,291(14):1701-1712

共引文献18

同被引文献15

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部