摘要
目的:探讨了妊高征患者治疗前后血浆leptin和血清Hcy、NPY水平的变化及临床意义。方法:应用放免法和酶联法对33例妊高征患者进行了治疗前后血浆leptin和血清Hcy、NPY检测,并与35例正常健康人作比较。结果:妊高征患者在治疗前血浆leptin和血清Hcy、NPY均非常显著地高于正常人组(P<0.01),经治疗1个月后与正常人组比较仍有显著性差异(P<0.05)。结论:检测妊高征患者血浆leptin和血清Hcy、NPY水平的变化已被认可用于疗效观察和预后判断。
Objective To explore the clinical significance of changes on plasma leptin, serum Hey and NPY levels after treat- ment in patients with pregnancy induced hypertension （PIH）. Methods plasma leptin, serum NPY （with RIA） and Hcy （with ELISA）, levels were determined in 33 patients with PIH both before and after treatment as well as in 35 normal controls. Results Be- fore treatment plasma leptin and serum Hcy, NPY levels in patients with PIH were significantly higher than those in controls （P 〈 0.01 ）. After 1 month of treatment the levels dropped markedly but still remained notably higher （P 〈 0.05 ）. Conclusion Plasma leptin, serum Hcy and NPY levels were closely related to the diseases of PIH. Such changes has been recognized to be used observing efficacy of therapy and prognosis.
出处
《放射免疫学杂志》
CAS
2012年第2期138-140,共3页
Journal of Radioimmanology
关键词
妊高征
瘦素
同型半胱氨酸
神经肽Y
pregnancy induced hypertension（ PIH）, homocysteine（ Hey）, neuropeptide Y
