心力衰竭患儿治疗前后血清APN、BNP、ANF检测的临床意义被引量：3

Clinical Significance of Determination of Changes of Serum APN, BNP and ANF Levels After Treatment in Patients with Heart Failure

暂未订购

导出

摘要目的:探讨了心力衰竭患者治疗前后血清APN、BNP、ANF水平的变化及临床意义。方法:应用放免法和酶联法对30例心力衰竭患者进行了治疗前后血清APN、BNP和ANF检测,并与35名正常健康人作比较。结果:心力衰竭患者在治疗前血清APN水平非常显著地低于正常人组(P<0.01),而血清BNP、ANF水平则非常显著地高于正常人组(P<0.01),经治疗1个月后与正常人组比较仍有显著差异(P<0.05)。结论:检测心力衰竭患者血清APN、BNP和ANF水平的变化对疗效观察、预后判断均具有重要的临床价值。 Objective To explore the significance of changes on serum APN,BNP and ANF levels after treatment in patients with heart failure. Methods Serum BNP,ANF（with RIA） serum APN（with ELISA） levels were determined in 30 patients with heart failure both before and after treatment as well as in 35 normal controls.Results Before treatment,serum APN level was significantly lower than those in controls（P0.01）,but serum BNP,ANF levels were apparently higher（P0.01）.After 1 month of treatment,the levels dropped markedly,but still remained obviously higher（P0.05）.Conclusion Serum APN,BNP and ANF levels were closely related to the process of heart failure and were of clinical value of monitoring therapeutic effect and prognosis.

作者葛恒松胡敏高新春

机构地区江苏省沭阳县人民医院

出处《放射免疫学杂志》 CAS 2011年第5期517-518,共2页 Journal of Radioimmanology

关键词心力衰竭脂联素脑钠肽心钠素 heart failure adiponectin（APN） brain natriuretic peptide（BNP） atrial natriuretic factor（ANF）

分类号 R541 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献8

1陈静.CHD患者血清Hcy、MMP-9和ADP检测的临床意义[J].放射免疫学杂志,2010,23(5):584-585. 被引量：4
2Naderll BK,Shimada K,Fukuda D,et al.Implication of plasma coronary heart diseases[J].Heart,2004,90(5):528-530.
3肖创清,肖翠娥,蒋立,黄志红.CHD患者血清APN和TNF-α测定的临床意义[J].放射免疫学杂志,2009,22(4):345-346. 被引量：1
4Haidari M,Javadi E,Sanati A,et al.Evaluation of C-reactive protein a sensititive marker of inflammation as a risk factor for stable coronary artery diseases[J].Clin Biochem,2001,34(4):309-315.
5Zwaka TP,Hombac V,Torzewski J.C-reactive protein mediated low density lipoprotein uptake by macro-phages:implication for atherosclerosis[J].Circularion,2001,103(e):1194-1197.
6Pischon T,Giman CJ,Hollami-sligil GS,et al.Plasma adiponectin in men[J].JAMA,2004,291(14):1730-1737.
7Cowie MP,Mendei GF.BNP and ANF levels in heart failure[J].Cardiovasc Dis,2002,44(4):293-295.
8杜同信,王自正,王书奎,罗骏.AMI患者血浆BNP,ET,CRP,ANP水平变化与临床观察分析[J].放射免疫学杂志,2004,17(1):6-7. 被引量：18

二级参考文献19

1冯宗忱.动脉粥样硬化——血管壁的慢性炎症[J].中华心血管病杂志,2005,33(5):393-394. 被引量：66
2石文蕾,张煜,张维,宫玲,王慧婷,朱毅,郑柏生,殷民德.超敏C反应蛋白与老年冠心病严重程度的关系[J].国外医学（心血管疾病分册）,2005,32(3):182-184. 被引量：17
3Haidari M,Javadi E,Sanati A,et al.Evaluation of C-reactive prorein,a sensitive marker of inflammation,as a risk factor for stable coronary artery disease[J].Clin Biochem,2001,34(4):309-315.
4Zwaka TP,Hombac V,Torzewski J.C-reactive protein mediated low density lipoprotein uptake by macrophagas:implications for atherosclersis[J].Circulation,2001,103(9):1194-1197.
5Jeffery L,Anderson MD,Face JF,et al.Evaluation of C-reactive protein,an inflammatory marker and infection serology as risk factors for coronary disease and myocardial infarction[J].J Am Coil Cardiol,1998,32(1):35-42.
6Yamauchi T,gamon J,Waki H,et al.Globular adiponectin protected ob/ob mice from diabetes and apce-defieient mice from atheroscleroeis[J].J Biol Chem,2003,278(4):2461-2473.
7Yudkin JS,Kumari M,Humphries SE,et al.Inflammation,obesity,stres and coronary heart disease:is interleukin-6 the link?[J]Athero-sclerosis,2000,148(2):209-214.
8Pischon T,Giman CJ,Hotamisligil GS,et al.Plasma adiponectin leveh and risk of myocardial infarction in men[J].JAM.A,2004,291(14):1730-1737.
9[1]Ridker P M, Cushman M, Stampfre MJ, et al. Plasma concentration of C-reactive protein and risk of developing peripheral vascular. Circulation, 1998, 97:425.
10[2]Ridker PM, Rifai N, Pfeffer MA, et al. Inflammation, pravastatin and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Circulation, 1998, 98(9):839.