脑梗死患者治疗前后血清Hcy、FA、VitB_(12)检测的临床意义被引量：25

Clinical Significance of Determination of Changes of Serum Hcy,Folic Acid and Vitamin B_(12)Levels During Treatment in Patients with Cerebral Infarction

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摘要目的探讨了脑梗死患者治疗前后血清同型半胱氨酸(Hcy)、叶酸(FA)、维生素B12(VitB12)水平及临床意义。方法血清Hcy测定采用免疫分析法,FA、VitB12采用放射免疫分析。对36例脑梗死患者进行了治疗前后的血清Hcy、FA和VitB12的检测,并与30名正常健康人作比较。结果在治疗前脑梗死患者血清Hcy水平非常显著地高于正常人组(P<0.01),而FA和VitB12水平则显著低于正常人组(P<0.01),经治疗3个月后,血清Hcy、FA、VitB12水平与正常人组比较仍有显著差异(P<0.05)。结论检测脑梗死患者血清Hcy、FA、VitB12水平对其病情和预后判断均具有重要的临床价值。 Objective To investigate the clinical significance of changes of serum Hcy, folic acid and vitamin B12 levels both before and after treatment in patients with cerebral infarction. Methods Serum Hcy level was measured with immunochemistry and serum folic acid and vitamin B12 levels were detected with RIA both before and ＇after treatment in 36 patients with cerebral infarction and 30 controls. Results Before treatment. The serum level of Hcy was significantly higher and serum folic acid, vitamin B12 levels significantly lower in the patients than those in controls （P 〈0. 01 ）. After treatment for 3 months. The serum Hcy, folio acid, vitamin Bn levels were much corrected but still remained significantly different from those in the controls （P 〈 0. 05 ）. Conclusion Determi- nation of serum Hcy, folic acid and vitamin B12 levels is clinically useful in the management in patients with cerebral infarction.

作者刘丽艳

机构地区江苏省连云港市东方医院神经内科

出处《放射免疫学杂志》 CAS 2006年第6期492-493,共2页 Journal of Radioimmanology

关键词脑梗死同型半胱氨酸叶酸维生素B12 cerebral infarction, homocysteine .（Hcy）, folic acid （ FA）, vitamin B12 （ VitB12 ）

分类号 R743.33 [医药卫生—神经病学与精神病学]

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