摘要
目的:探讨慢性肾炎患者治疗前后血浆leptin和血清IL-6、IL-18及SOD水平的变化及临床意义。方法:应用放射免疫分析和酶联免疫法对33例慢性肾炎患者进行了血浆leptin和血清IL-6、IL-18及SOD检测,并与35名正常健康人作比较。结果:慢性肾炎患者在治疗前血浆leptin和血清IL-6、IL-18均显着地高于正常人组(P<0.01),而血清SOD水平则显着地低于正常人组(P<0.01)。经中西医结合治疗3个月后与正常人组比较仍有显著性差异(P<0.05),血浆leptin水平与血清IL-6、IL-18水平呈正相关(r=0.5718、0.4916,P<0.01),而与SOD水平呈负相关(r=-0.6018,P<0.01)。结论:检测慢性肾炎患者治疗前后血浆leptin和血清IL-6、IL-18及SOD水平的变化对临床观察和预后有重要的临床价值。
Objective To explore the clinical significance of changes on plasma leptin and serum IL-6, IL-18, SOD levels after treatment in patients with chronic nephritis. Methods Plasma leptin and serum SOD （with RIA）, serum IL-6, IL-18 （with ELISA） levels were measured in 33 patients with chronic nephritis as well as 35 normal healthy controls. Results Before treatment, the plas- ma leptin and serum IL-6, IL-18 were obviously higher than those in controls （P 〈0.01 ）, while the serum SOD level was significantly lower （P 〈 0.01 ）. After treatment for 3 months, the levels in patients though dropped markedly remained higher than those in controls （P 〈 0.05 ）. Plasma leptin level was positively correlated with IL-6, IL-8 levels（r = 0.5718,0.4916, P 〈 0.01 ）, while the negative correlated with SOD level（r = - 0.6018, P 〈 0.01 ）. Conclusion Changes of plasma leptin and serum IL-6, IL-18, SOD levels af- ter treatment might be of prognostic importance in patients with chronic nephritis and provided important clinical value.
出处
《放射免疫学杂志》
CAS
2012年第2期125-127,共3页
Journal of Radioimmanology
关键词
慢性肾炎瘦素
白介素6
白介素18
超氧化物岐化酶
chronic nephritis, leptin, interleukin-6 （ IL-6 ）, interleukin （ IL-I 8 ）, superoxide dismutase （SOD）
