摘要
四环素类药物是抑制细菌蛋白合成的一大类广谱抗生素,广泛用于多种细菌及立克次氏体、衣原体、支原体等所致之感染。四环素类药物由Ⅱ型聚酮体途径(polyketide synthase,PKSⅡ)合成,通过一套可重复使用的结构域在重复的反应步骤中多次催化酚聚酮结构的生成。该类化合物的结构多样性主要来源于聚酮合成后的修饰。本文对四环素类药物的生物合成途径及关键酶调控机制的研究进展展开综述。
Tetracyclines are broad spectrum antibiotics which can inhibit protein synthesis and are widely used to treat various bacterial infections. The biosynthesis cluster of tetracyclines belongs to type Ⅱ polyketide synthase （PKS Ⅱ ） which generates the poly-β-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units followed by modifications by cyclases, oxygenases, transferases and additional tailoring enzymes. Genetic and biochemical studies have illustrated most of the steps involved in the biosynthesis of tetracyclines, which may be helpful to better understanding and regulation of the biosynthesis of this type of polyketides.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2012年第4期306-310,共5页
Chinese Journal of Pharmaceuticals
关键词
四环素
生物合成
调控机制
综述
tetracycline
biosynthesis
regulation mechanism
review
