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土霉素生物合成研究进展 被引量：3

Advances in oxytetracycline biosynthesis by Streptomyces rimosus
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摘要 本文介绍了近年来土霉素的生物合成研究进展,包括基因簇结构、土霉素分子调控等,以及运用基因工程和组合生物合成原理创造新型土霉素结构类似物的前景。 This paper focuses on the research progress of oxytetracycline （OTC） biosynthesis in recent years, including OTC gene cluster architecture and its molecular regulation. And the prospective study of novel oxytetracycline analogs with genetic engineering and combinatorial biosynthesis technology was also addressed.
作者 唐振宇 郭美锦 张嗣良
机构地区 华东理工大学生物反应器工程国家重点实验室
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2009年第10期581-587,601,共8页 Chinese Journal of Antibiotics
基金 国家重点实验室专项(No.2060204) 国家留学回国人员启动基金
关键词 龟裂链霉菌 土霉素 生物合成基因簇 分子调控 Streptomyces rimosus Oxytetracycline Biosynthetic gene cluster Molecular regulation
分类号 TQ465.4 [化学工程—制药化工]
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参考文献34

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二级参考文献71

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中国抗生素杂志
2009年 第10期

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