摘要
目的 :研究电刺激小脑顶核对血管性痴呆 (vasculardementia ,VD)大鼠的治疗作用与机制。方法 :持久性双侧颈总动脉结扎造成老龄大鼠慢性前脑灌注不足 ,建立近似人类学习记忆障碍的大鼠VD模型。治疗组大鼠小脑顶核给予电刺激 ,用电脑控制穿梭箱系统检测大鼠的认知能力。结果 :慢性前脑灌注不足 2个月后大鼠学习记忆能力均下降 ,4个月后更明显 ;电刺激痴呆大鼠小脑顶核后 ,学习及记忆能力明显提高 ,学习提高更明显。结论 :电刺激小脑顶核可显著改善痴呆的大鼠的认知能力。
Objective:To investigate the effect and mechanism of fastigial nucleus stimulation (FNS) treating vascular dementia(VD) in aging rats.Method:Chronic frontal cerebral hypoperfusion was performed in aging rats by permanent bilateral common carotid artery occlusion (PBCCAO) method, thus the animal VD model was established. The cognitive function of rats was measured in a computerized shuttle training case before and after FNS.Result:The cognitive function of rats was obviously reduced after two months of the chronic cerebral hypoperfusion and became worse four months of that hypoperfusion, but it was distinctly improved after FNS.Conclusion:FNS could greatly improve the cognitive function of VD in aging rats. Author′s address Dept. of Neurology,First Hospital,the Third Military Medical University,Chongqing,400038
出处
《中国康复医学杂志》
CAS
CSCD
2000年第3期132-134,共3页
Chinese Journal of Rehabilitation Medicine
基金
国家自然科学基金资助项目 !编号:39770273
关键词
小脑顶核
血管性痴呆
电刺激
大鼠
Fastigial nucleus
Vascular dementia
Electric stimulation
Aging rat
