摘要
目的 探讨创伤急性期血浆内八肽胆囊收缩素 (CCK 8)、血管加压素 (VIP)、生长抑素 (SS)和胃泌素 (GAS)含量的变化。方法 放免法测定中重度创伤患者血浆内CCK 8、VIP、SS、GAS含量变化 ,测定大鼠断肢创伤后 0、1、2、3、6h血浆内CCK 8、VIP含量的动态变化。结果 中重度创伤患者急性期血浆内CCK 8、VIP、GAS含量明显升高 ,SS含量降低 (P <0 .0 5 ) ,大鼠断肢后即刻CCK 8含量升高 (P <0 .0 5 ) ,1h后恢复正常 ,血浆内VIP含量于断肢后 1h、2h明显升高 (P <0 .0 5 ) ,后逐渐恢复正常。结论 各种创伤作为应激源可致体内相关神经肽含量变化 ,并参与机体的应激反应。
Objective To evaluate the changes of plasma CCK 8、VIP、SS、GAS during actue stage of trauma.Methods The contents of CCK 8、VIP、SS、GAS in plasma of severely traumatic patients and rats were assessed.Results In traumatic patients, plasma levels of CCK 8、SS、GAS were higher than those in the controls, whereas the content of VIP was decreased. In fracture rats, plasma level of CCK 8 was immediately increased whereas of VIP rose at 1 and 2 hours after trauma as compared with controls, there were no significant changes in other periods.Conclusion Plasma levels of many neuropeptides change significantly after trauma, which may be the responses to the stress periods. (Shanghai Med J, 2000,23:293 295)
出处
《上海医学》
CAS
CSCD
北大核心
2000年第5期293-295,共3页
Shanghai Medical Journal
基金
军队医药杰出中青年科研基金
