摘要
目的 研究精神分裂症多发家系成员的血浆白细胞介素 6 (IL 6 )浓度的变化。方法将 42个精神分裂症多发家系的 2 2 2名成员分为父母组 (84名 ,男女各 42名 )、患病同胞组 (92例 ,男 45例 ,女 47例 )和非患病同胞组 (46名 ,男 2 2名 ,女性 2 4名 ) ,另将 6 2名健康人 (男 2 4名 ,女 38名 )作为正常对照。用酶联免疫吸附法检测各组受试者血浆IL 6浓度 ,并进行组间比较。在 42个家系中 ,每个家系的成员中至少要有 2例按国际疾病分类第 10版诊断为精神分裂症。结果 (1)父母组的血浆IL 6浓度 [(6 2± 5 0 )pmol/L]与患病同胞组 [(6 0± 5 0 )pmol/L]和非患病同胞组 [(6 3± 5 3)pmol/L]的差异无显著性 ,但均高于健康人组 [(2 5± 37)pmol/L],P <0 0 1;(2 )患病同胞组发病期患者的血浆IL 6浓度 [(82± 6 0 )pmol/L]高于缓解期患者 [(5 0± 41)pmol/L],P <0 0 5 ,且不受服药或吸烟的影响 ;(3)患病同胞组血浆IL 6浓度与是否和父母、同胞居住在一起无关 ;(4)逐步回归分析结果显示 ,患者血浆IL 6浓度与临床症状评分 (包括阴性症状量表总分、阴性症状分量表综合评价总分、意志缺乏 /淡漠总评分、快感缺乏 /社交缺乏总评分、思维形式障碍严重程度总评分 )呈正相关 (P <0 0 5 ) ,与社会功能受损程度呈负相关。
Objective The purpose of this study was to measure the plasma concentration of the interleukin 6 (IL 6) in schizophrenic multiplex families Methods All of the 222 members from 42 schizophrenic multiplex families were grouped into three subgroups: parents group (PG), schizophrenic siblings (SS) group and non schizophrenic siblings (NSS) group besides a normal control group (NCG) for comparison The IL 6 level of PG, SS, NSS and NCG were measured with ELISA The multiplex family was identified that at least two siblings were diagnosed as schizophrenia by ICD 10 Results (1) No significant differences of IL 6 was found among the PG [(62±50)pmol/L], SS [(60±50)pmol/L] and NSS [(63±53)pmol/L] However the IL 6 level in each of the three groups in multiplex families was significantly higher than in normal control group [(25±37)pmol/L], respectively, P <0.01 (2) The IL 6 level of those schizophrenic siblings in stage of attack [(82±60)pmol/L] was significantly higher than those in remission stage [(50±41)pmol/L], P <0 05 It was found that using neuroleptic therapy or smoking did not effect the change of IL 6 concentration in schizophrenic siblings (3)It was found that living with parents or sibling did not effect the change of IL 6 concentration in schizophrenic siblings (4)Stepwise regressive analysis showed that the IL 6 level in the schizophrenic siblings was positively related to the scores of positive formal thought disorder, sub scale of negative symptoms, global rating of sub scale of negative symptoms, avolition/apathy, and anhedonia/asociality( P <0 05),respectively However, it was significantly negatively related to their social function impairment ( P <0 05) Conclusions (1)The increase of plasma IL 6 level in the member of schizophrenic multiplex families might be involved in the susceptibility or the pathophysiological mechanism of schizophrenia developing (2) The IL 6 level of schizophrenia was closely related to clinical symptoms
出处
《中华精神科杂志》
CAS
CSCD
2000年第2期85-88,共4页
Chinese Journal of Psychiatry
